PIG-X

PIG-X / PBN1

• SMART accession number: SM00780
• Description: Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.
• Interpro abstract (IPR013233):

  Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I [ (PUBMED:15635094) ]. These enzymes are involved in the transfer of sugar molecules. They probably act by stabilizing the mannosyltransferase PIG-M (GPI14 in yeast) [ (PUBMED:15635094) (PUBMED:16418276) ].

• GO process: GPI anchor biosynthetic process (GO:0006506)
• GO component: endoplasmic reticulum membrane (GO:0005789)

There are 1054 PIG-X domains in 1054 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Cellular role: metabolism

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
50.00	map00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
50.00	map01031	Glycan structures - biosynthesis 2

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PIG-X domain which could be assigned to a KEGG orthologous group, and not all proteins containing PIG-X domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Links (links to other resources describing this domain)

• PFAM: PIG-X
• INTERPRO: IPR013233