AFOR_N

Aldehyde ferredoxin oxidoreductase, N-terminal domain
AFOR_N
SMART accession number:SM00790
Description: Enzymes of the aldehyde ferredoxin oxidoreductase (AOR) family (PUBMED:9242907) contain a tungsten cofactor and an 4Fe4S cluster and catalyse the interconversion of aldehydes to carboxylates (PUBMED:8672295). This family includes AOR, formaldehyde ferredoxin oxidoreductase (FOR), glyceraldehyde-3-phosphate ferredoxin oxidoreductase (GAPOR), all isolated from hyperthermophilic archea (PUBMED:9242907); carboxylic acid reductase found in clostridia (PUBMED:2550230); and hydroxycarboxylate viologen oxidoreductase from Proteus vulgaris, the sole member of the AOR family containing molybdenum (PUBMED:8026480). GAPOR may be involved in glycolysis (PUBMED:7721730), but the functions of the other proteins are not yet clear. AOR has been proposed to be the primary enzyme responsible for oxidising the aldehydes that are produced by the 2-keto acid oxidoreductases (PUBMED:9275170).
Interpro abstract (IPR013983):

Enzymes of the aldehyde ferredoxin oxidoreductase (AOR) family [ (PUBMED:9242907) ] contain a tungsten cofactor and an 4Fe4S cluster and catalyse the interconversion of aldehydes to carboxylates [ (PUBMED:8672295) ]. This family includes AOR, formaldehyde ferredoxin oxidoreductase (FOR), glyceraldehyde-3-phosphate ferredoxin oxidoreductase (GAPOR), all isolated from hyperthermophilic archea [ (PUBMED:9242907) ]; carboxylic acid reductase found in clostridia [ (PUBMED:2550230) ]; and hydroxycarboxylate viologen oxidoreductase from Proteus vulgaris, the sole member of the AOR family containing molybdenum [ (PUBMED:8026480) ]. GAPOR may be involved in glycolysis [ (PUBMED:7721730) ], but the functions of the other proteins are not yet clear. AOR has been proposed to be the primary enzyme responsible for oxidising the aldehydes that are produced by the 2-keto acid oxidoreductases [ (PUBMED:9275170) ].

This entry represents the N-terminal domain of these enzymes. This domain has been shown to interact with the tungsten cofactor [ (PUBMED:7878465) ].

GO process:oxidation-reduction process (GO:0055114)
GO function:oxidoreductase activity (GO:0016491), iron-sulfur cluster binding (GO:0051536), oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor (GO:0016625)
Family alignment:
View or

There are 5747 AFOR_N domains in 5747 proteins in SMART's nrdb database.

Click on the following links for more information.