TAP_C

C-terminal domain of vertebrate Tap protein
TAP_C
SMART accession number:SM00804
Description: The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain.
Interpro abstract (IPR005637):

The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling [(PUBMED:11875519)]. The structure of the C-terminal domain is composed of four helices [(PUBMED:11875519)]. The structure is related to the UBA domain.

GO process:mRNA transport (GO:0051028)
GO component:nucleus (GO:0005634)
Family alignment:
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There are 580 TAP_C domains in 574 proteins in SMART's nrdb database.

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