EFG_C

Elongation factor G C-terminus

• SMART accession number: SM00838
• Description: This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a ferredoxin-like fold.
• Interpro abstract (IPR000640):

  Elongation factor 2 (EF2 or EFG) is folded into five domains, with domains I and II forming the N-terminal block, domains IV and V forming the C-terminal block, and domain III providing the covalently-linked flexible connection between the two [ (PUBMED:11054294) ]. This entry represents the domain V of EF2 of both prokaryotes and eukaryotes (also known as eEF2). This domain is also found in elongation factor 4 and some tetracycline resistance proteins and adopts a ferredoxin-like fold [ (PUBMED:12471894) ].

There are 76176 EFG_C domains in 76171 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Cellular role: translation

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
33.33	map00450	Selenoamino acid metabolism
33.33	map00230	Purine metabolism
33.33	map00920	Sulfur metabolism

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EFG_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing EFG_C domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of EFG_C domains in PDB

PDB code	Title
1dar	ELONGATION FACTOR G IN COMPLEX WITH GDP
1efg	THE CRYSTAL STRUCTURE OF ELONGATION FACTOR G COMPLEXED WITH GDP, AT 2.7 ANGSTROMS RESOLUTION
1elo	ELONGATION FACTOR G WITHOUT NUCLEOTIDE
1fnm	STRUCTURE OF THERMUS THERMOPHILUS EF-G H573A
1jqm	Fitting of L11 protein and elongation factor G (EF-G) in the cryo-em map of e. coli 70S ribosome bound with EF-G, GDP and fusidic acid
1jqs	Fitting of L11 protein and elongation factor G (domain G' and V) in the cryo-em map of E. coli 70S ribosome bound with EF-G and GMPPCP, a nonhydrolysable GTP analog
1ktv	Crystal Structure of Elongation Factor G Dimer Without Nucleotide
1n0u	Crystal structure of yeast elongation factor 2 in complex with sordarin
1n0v	Crystal structure of elongation factor 2
1pn6	Domain-wise fitting of the crystal structure of T.thermophilus EF-G into the low resolution map of the release complex.Puromycin.EFG.GDPNP of E.coli 70S ribosome.
1u2r	Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae
1wdt	Crystal structure of ttk003000868 from Thermus thermophilus HB8
1zm2	Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA
1zm3	Structure of the apo eEF2-ETA complex
1zm4	Structure of the eEF2-ETA-bTAD complex
1zm9	Structure of eEF2-ETA in complex with PJ34
1zn0	Coordinates of RRF and EF-G fitted into Cryo-EM map of the 50S subunit bound with both EF-G (GDPNP) and RRF
2bm0	Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant T84A
2bm1	Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant T84A.
2bv3	Crystal structure of a mutant elongation factor G trapped with a GTP analogue
2dy1	Crystal structure of EF-G-2 from Thermus thermophilus
2e1r	Structure of eEF2 in complex with a sordarin derivative
2efg	TRANSLATIONAL ELONGATION FACTOR G COMPLEXED WITH GDP
2j7k	Crystal structure of the T84A mutant EF-G:GDPCP complex
2mzw	2MZW
2npf	Structure of eEF2 in complex with moriniafungin
2om7	Structural Basis for Interaction of the Ribosome with the Switch Regions of GTP-bound Elongation Factors
2p8w	Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction
2p8x	Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDPNP cryo-EM reconstruction
2p8y	Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDP:sordarin cryo-EM reconstruction
2p8z	Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDPNP:sordarin cryo-EM reconstruction
2rdo	50S subunit with EF-G(GDPNP) and RRF bound
2xex	crystal structure of Staphylococcus aureus elongation factor G
2ywe	Crystal structure of LepA from Aquifex aeolicus
2ywf	Crystal structure of GMPPNP-bound LepA from Aquifex aeolicus
2ywg	Crystal structure of GTP-bound LepA from Aquifex aeolicus
2ywh	Crystal structure of GDP-bound LepA from Aquifex aeolicus
2zit	Structure of the eEF2-ExoA-NAD+ complex
3b78	Structure of the eEF2-ExoA(R551H)-NAD+ complex
3b82	Structure of the eEF2-ExoA(E546H)-NAD+ complex
3b8h	Structure of the eEF2-ExoA(E546A)-NAD+ complex
3cb4	The Crystal Structure of LepA
3deg	Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP
3dny	Fitting of the eEF2 crystal structure into the cryo-EM density map of the eEF2.80S.AlF4-.GDP complex
3e3x	The C-terminal part of BipA protein from Vibrio parahaemolyticus RIMD 2210633
3izp	Conformation of EF-G during translocation
3j0e	Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex
3j25	Structural basis for TetM-mediated tetracycline resistance
3j7p	3J7P
3j9y	3J9Y
3j9z	3J9Z
3ja1	3JA1
3jb9	3JB9
3jcd	3JCD
3jce	3JCE
3jcm	3JCM
3jcr	3JCR
3zz0	Crystal structure of ribosomal elongation factor (EF)-G from Staphylococcus aureus with a fusidic acid hyper-sensitivity mutation M16I
3zzt	Crystal structure of Staphylococcus aureus elongation factor G with a fusidic-acid-resistant mutation F88L
3zzu	Crystal structure of Staphylococcus aureus elongation factor G with mutations M16I and F88L
4fn5	ELONGATION FACTOR G 1 (PSEUDOMONAS AERUGINOSA) IN COMPLEX WITH Argyrin B
4m1k	4M1K
4myt	4MYT
4myu	4MYU
4v4b	4V4B
4v5f	4V5F
4v5m	4V5M
4v5n	4V5N
4v6t	4V6T
4v6v	4V6V
4v6w	4V6W
4v6x	4V6X
4v7b	4V7B
4v7d	4V7D
4v8u	4V8U
4v90	4V90
4v9h	4V9H
4v9j	4V9J
4v9k	4V9K
4v9l	4V9L
4v9m	4V9M
4v9o	4V9O
4v9p	4V9P
4w29	4W29
4w2e	4W2E
4wpo	4WPO
4wqf	4WQF
4wqu	4WQU
4wqy	4WQY
4zci	4ZCI
4zck	4ZCK
4zcl	4ZCL
4zcm	4ZCM
5a9v	5A9V
5a9w	5A9W
5a9x	5A9X
5a9y	5A9Y
5a9z	5A9Z
5aa0	5AA0
5anb	5ANB
5anc	5ANC
5gam	5GAM
5gan	5GAN
5gm6	5GM6
5gmk	5GMK
5hau	5HAU
5imq	5IMQ
5imr	5IMR
5it7	5IT7
5j8b	5J8B
5juo	5JUO
5jup	5JUP
5jus	5JUS
5jut	5JUT
5juu	5JUU
5kcs	5KCS
5lj3	5LJ3
5lj5	5LJ5
5lqw	5LQW

Links (links to other resources describing this domain)

• PFAM: EFG_C
• INTERPRO: IPR000640