Alpha-mann_mid

Alpha mannosidase, middle domain

• SMART accession number: SM00872
• Description: Members of this entry belong to the glycosyl hydrolase family 38, This domain, which is found in the central region adopts a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. The domain is predominantly found in the enzyme alpha-mannosidase (PUBMED:12634058).

There are 515 Alpha-mann_mid domains in 515 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Cellular role: metabolism

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
43.57	map00511	N-Glycan degradation
43.57	map01032	Glycan structures - degradation
5.81	map00510	N-Glycan biosynthesis
5.81	map01030	Glycan structures - biosynthesis 1
1.24	map00530	Aminosugars metabolism

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Alpha-mann_mid domain which could be assigned to a KEGG orthologous group, and not all proteins containing Alpha-mann_mid domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of Alpha-mann_mid domains in PDB

PDB code	Title
1hty	Golgi alpha-mannosidase ii
1hww	Golgi alpha-mannosidase ii in complex with swainsonine
1hxk	Golgi alpha-mannosidase ii in complex with deoxymannojirimicin
1ps3	Golgi alpha-mannosidase ii in complex with kifunensine
1qwn	Golgi alpha-mannosidase ii covalent intermediate complex with 5-fluoro-gulosyl-fluoride
1qwu	Golgi alpha-mannosidase ii d341n mutant complex with 5-f- guloside
1qx1	Golgi alpha-mannosidase ii d341n mutant complex with 2-f- mannosyl-f
1r33	Golgi alpha-mannosidase ii complex with 5-thio-d- mannopyranosylamine
1r34	Golgi alpha-mannosidase ii complex with 5-thio-d- mannopyranosylamidinium salt
1tqs	Golgi alpha-mannosidase ii in complex with salacinol
1tqt	Golgi alpha-mannosidase ii in complex with a diastereomer of salacinol
1tqu	Golgi alpha-mannosidase ii in complex with the salacinol analog ghavamiol
1tqv	Golgi alpha-mannosidase ii in complex with seleno-salacinol (blintol)
1tqw	Golgi alpha-mannosidase ii in complex with a diastereomer of seleno-salacinol
2alw	Golgi alpha-mannosidase ii complex with noeuromycin
2f18	Golgi alpha-mannosidase ii complex with (2r,3r,4s)-2- ({[(1r)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidine-3, 4-diol
2f1a	Golgi alpha-mannosidase ii complex with (2r,3r,4s)-2- ({[(1s)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidine-3, 4-diol
2f1b	Golgi alpha-mannosidase ii complex with (2r,3r,4s,5r)-2- ({[(1r)-2-hydroxy-1-phenylethyl]amino}methyl)-5- methylpyrrolidine-3,4-diol
2f7o	Golgi alpha-mannosidase ii complex with mannostatin a
2f7p	Golgi alpha-mannosidase ii complex with benzyl-mannostatin a
2f7q	Golgi alpha-mannosidase ii complex with aminocyclopentitetrol
2f7r	Golgi alpha-mannosidase ii complex with benzyl- aminocyclopentitetrol
2fyv	Golgi alpha-mannosidase ii complex with an amino-salacinol carboxylate analog
2ow6	Golgi alpha-mannosidase ii complex with (1r,5s,6s,7r,8s)-1- thioniabicyclo[4.3.0]nonan-5,7,8-triol chloride
2ow7	Golgi alpha-mannosidase ii complex with (1r,6s,7r,8s)-1- thioniabicyclo[4.3.0]nonan-7,8-diol chloride
3blb	Crystal structure of golgi mannosidase ii in complex with swainsonine at 1.3 angstrom resolution
3bub	Golgi alpha-mannosidase ii with an empty active site
3bud	Golgi mannosidase ii d204a catalytic nucleophile mutant with an empty active site
3bui	Golgi mannosidase ii d204a catalytic nucleophile mutant complex with tris
3bup	Golgi alpha-mannosidase ii d341n acid-base catalyst mutant with bound mannose
3buq	Golgi alpha-mannosidase ii d204a catalytic nucleophile mutant with bound mannose.
3bvt	Golgi mannosidase ii d204a catalytic nucleophile mutant complex with methyl (alpha-d-mannopyranosyl)-(1->3)-s- alpha-d-mannopyranoside
3bvu	Golgi mannosidase ii d204a catalytic nucleophile mutant complex with methyl(alpha-d-mannopyranosyl)-(1->3)-s- [(alpha-d-mannopyranosyl)-(1->6)]-alpha-d-mannopyranoside
3bvv	Golgi mannosidase ii d204a catalytic nucleophile mutant complex with methyl alpha-d-mannopyranosyl-(1->3)-[6-thio- alpha-d-mannopyranosyl-(1->6)]-beta-d-mannopyranoside
3bvw	Golgi mannosidase ii d204a catalytic nucleophile mutant complex with methyl (2-deoxy-2-acetamido-beta-d- glucopyranosyl)-(1->2)-alpha-d-mannopyranosyl- (1->3)- [alpha-d-mannopyranosyl-(1->6)-6-thio-alpha-d- mannopyranosyl- (1->6)]-beta-d-mannopyranoside
3bvx	Golgi mannosidase ii d204a catalytic nucleophile mutant complex with methyl (2-deoxy-2-acetamido-beta-d- glucopyranosyl)-(1->2)-(alpha-d-mannopyranosyl)- (1->3)- [(alpha-d-mannopyranosyl)-(1->6)-(alpha-d-mannopyranosyl)- (1->6)]-beta-d-mannopyranoside
3cv5	Golgi mannosidase ii d204a catalytic nucleophile mutant complex with 3alpha,6alpha-mannopentaose
3czn	Golgi alpha-mannosidase ii (d204a nucleophile mutant) in complex with gnman5gn
3czs	Golgi alpha-mannosidase ii (d204a nucleophile mutant)
3d4y	Golgi mannosidase ii complex with mannoimidazole
3d4z	Golgi mannosidase ii complex with gluco-imidazole
3d50	Golgi mannosidase ii complex with n-octyl-6-epi-valienamine
3d51	Golgi mannosidase ii complex with gluco-hydroxyiminolactam
3d52	Golgi mannosidase ii complex with an n-aryl carbamate derivative of gluco-hydroxyiminolactam
3ddf	Golgi mannosidase ii complex with (3r,4r,5r)-3,4-dihydroxy- 5-({[(1r)-2-hydroxy-1 phenylethyl]amino}methyl) pyrrolidin- 2-one
3ddg	Golgi mannosidase ii complex with (3r,4r,5r)-3,4-dihydroxy- 5-({[(1r)-2-hydroxy-1 phenylethyl]amino}methyl) methylpyrrolidin-2-one
3dx0
3dx1
3dx2
3dx3
3dx4
3ejp
3ejq
3ejr
3ejs
3ejt
3eju

Links (links to other resources describing this domain)

• PFAM: Alpha-mann_mid