BACK

BTB And C-terminal Kelch
BACK
SMART accession number:SM00875
Description: The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.
Interpro abstract (IPR011705):

This domain is found associated with (IPR000210) and (IPR006652). BTB (broad-complex, tramtrack and bric a brac) is a Kelch related domain, also known as the POZ domain [(PUBMED:16207353)]. BTB proteins are divided into subgroups depending on what domain lies at the C terminus. Despite the divergence in sequences, the BTB fold is highly conserved.

BTB-Kelch proteins have Kelch repeats that form a beta-propeller that can interact with actin filaments [(PUBMED:15544948)]. BTB and C-terminal Kelch (BACK) together constitute a novel conserved domain, which is thought to have a possible role in substrate orientation in Cullin3-based E3 ligase complexes.

Four domains, namely the BTB domain, a kelch domain, a BACK domain, and an intervening region (IVR) make up the aryl hydrocarbon receptor (AHR); a ligand-activated transcription factor [(PUBMED:16582008)]. This entry represents the domain associated with BTB and Kelch.

Family alignment:
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There are 9154 BACK domains in 9119 proteins in SMART's nrdb database.

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