Tim44

Tim44
SMART accession number:SM00978
Description: Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane (PUBMED:10430866). Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region (PUBMED:10430866).
Interpro abstract (IPR007379):

Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane [(PUBMED:10430866)]. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region [(PUBMED:10430866)].

GO process:intracellular protein transport (GO:0006886)
GO component:mitochondrial inner membrane presequence translocase complex (GO:0005744)
GO function:P-P-bond-hydrolysis-driven protein transmembrane transporter activity (GO:0015450)
Family alignment:
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There are 816 Tim44 domains in 816 proteins in SMART's nrdb database.

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