BRO1-like domain
SMART accession number:SM01041
Description: This domain is found in a number proteins including Rhophilin Q61085 and BRO1 P48582. It is known to have a role in endosomal targeting. ESCRT-III subunit Snf7 binds to a conserved hydrophobic patch in the BRO1 domain that is required for protein complex formation and for the protein-sorting function of BRO1 (PUBMED:15935782).
Interpro abstract (IPR004328):

The BRO1 domain is a protein domain of ~390 residues in length. It occurs in a number of eukaryotic proteins, such as yeast BRO1 and human PDCD6IP/Alix, which are involved in protein targeting to the vacuole or lysosome. The BRO1 domain of fungal and mammalian proteins binds with multivesicular body components (ESCRT-III proteins) such as yeast Snf7 and mammalian CHMP4b, and can function to target BRO1 domain-containing proteins to endosomes [ (PUBMED:15935782) (PUBMED:14583093) (PUBMED:15944343) ].

The BRO1 domain has a boomerang shape composed of 14 alpha-helices and 3 beta-sheets. It contains a TPR-like substructure in the central part [ (PUBMED:15935782) ]. The C terminus is less conserved.

Family alignment:
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There are 5823 BRO1 domains in 5818 proteins in SMART's nrdb database.

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