BTD

Beta-trefoil DNA-binding domain
BTD
SMART accession number:SM01268
Description: Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR) (PUBMED:15297877).
Interpro abstract (IPR015350):

This DNA-binding domain adopts a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and corepressors (SMRT/N-Cor and CIR) [(PUBMED:15297877)].

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO function:RNA polymerase II proximal promoter sequence-specific DNA binding (GO:0000978), transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding (GO:0000982)
Family alignment:
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There are 1505 BTD domains in 1502 proteins in SMART's nrdb database.

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