S_100

S-100/ICaBP type calcium binding domain
S_100
SMART accession number:SM01394
Description: -
Interpro abstract (IPR013787):

The calcium-binding domain found in S100 and CaBP-9k proteins is a subfamily of the EF-hand calcium-binding domain [(PUBMED:15284904)]. S100s are small dimeric acidic calcium and zinc-binding proteins abundant in the brain, with S100B playing an important role in modulating the proliferation and differentiation of neurons and glia cells [(PUBMED:15006498)]. S100 proteins have two different types of calcium-binding sites: a low affinity one with a special structure, and a 'normal' EF-hand type high-affinity site.

Calbindin-D9k (CaBP-9k) also belong to this family of proteins, but it does not form dimers. CaBP-9k is a cytosolic protein expressed in a variety of tissues. Although its precise function is unknown, it appears to be under the control of the steroid hormones oestrogen and progesterone in the female reproductive system [(PUBMED:16288660)]. In the intestine, CaBP-9k may be involved in calcium absorption by mediating intracellular diffusion [(PUBMED:12520541)].

This entry represents a subdomain of the calcium-binding domain found in S100, CaBP-9k, and related proteins.

Family alignment:
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There are 5617 S_100 domains in 5516 proteins in SMART's nrdb database.

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