Sec7 domain
SMART accession number:SM00222
Description: Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).
Interpro abstract (IPR000904): The Sec7 domain was named after the first protein found to contain such a region [(PUBMED:3042778)]. It has been shown to be linked with guanine nucleotide exchange function [(PUBMED:9072969), (PUBMED:9442017)]. The 3D structure of the domain displays several alpha-helices [(PUBMED:9653114)]. It was found to be associated with other domains involved in guanine nucleotide exchange (e.g., CDC25, Dbl) in mammalian factors [(PUBMED:9868368)].
GO process:regulation of ARF protein signal transduction (GO:0032012)
GO function:ARF guanyl-nucleotide exchange factor activity (GO:0005086)
Family alignment:
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There are 3676 Sec7 domains in 3673 proteins in SMART's nrdb database.

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