TAP_C

C-terminal domain of vertebrate Tap protein
TAP_C
SMART accession number:SM00804
Description: The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain.
Interpro abstract (IPR005637):

The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling [(PUBMED:11875519)]. The structure of the C-terminal domain is composed of four helices [(PUBMED:11875519)]. The structure is related to the UBA domain.

The NXF family of mRNA nuclear export factors includes vertebrate NXF1 (also called tip-associated protein or mRNA export factor TAP), NXF2 (also called cancer/testis antigen CT39 or TAP-like protein TAPL-2), Caenorhabditis elegans NXF1 (ceNXF1), Saccharomyces cerevisiae mRNA nuclear export factor Mex67p and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. An NXF protein is multi-domain with a nuclear localization sequence (NLS), a non-canonical mRNA-binding domain, and four leucine-rich repeats (LLR) at the N-terminal region. Its C-terminal part contains a NTF2-like domain and a ubiquitin-associated (UBA)-like domain, joined by flexible Pro-rich linker. Caenorhabditis elegans NXF1 are essential for the nuclear export of poly(A)+mRNA. In budding yeast, Mex67p binds mRNAs through its adaptor Yra1/REF. It also interacts directly with Nab2, an essential shuttling mRNA-binding protein required for export. Moreover, Mex67p associates with both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX/THO complex linking transcription and export [(PUBMED:11875519), (PUBMED:20810649), (PUBMED:10567585), (PUBMED:11073998), (PUBMED:11583626), (PUBMED:12581645), (PUBMED:19401465), (PUBMED:11060011), (PUBMED:11256625), (PUBMED:10668806), (PUBMED:11259411), (PUBMED:9660949), (PUBMED:9175835), (PUBMED:10454577), (PUBMED:10323864), (PUBMED:10202158)].

GO process:mRNA transport (GO:0051028)
GO component:nucleus (GO:0005634)
Family alignment:
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There are 1825 TAP_C domains in 1815 proteins in SMART's nrdb database.

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