Domains within Aspergillus fischeri NRRL 181 protein DCL1_NEOFI (A1DE13)

Dicer-like protein 1

Alternative representations: 1 /

Protein length1538 aa
Source databaseUniProt
Identifiers DCL1_NEOFI, A1DE13

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

DCL1_NEOFI is shown as dcl1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for dcl1

Protein DCL1_NEOFI is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05205Proteoglycans in cancer
map05206MicroRNAs in cancer

KEGG orthologous groups

KONameDescription
K11592DICER1, DCR1endoribonuclease Dicer [EC:3.1.26.-]
K03685rnc, DROSHA, RNT1ribonuclease III [EC:3.1.26.3]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 331117.A1DE13 in eggNOG.

OGTaxonomic classDescription
LCOG0571All organisms (root)ribonuclease III [EC:3.1.26.3],endoribonuclease Dicer [EC:3.1.26.-],large subunit ribosomal protein L44 [EC:3.1.26.-]
FQKNCDikarya (subkingdom)endoribonuclease Dicer [EC:3.1.26.-],RAB6A-GEF complex partner protein 2
KOG0701Eukaryota (superkingdom)endoribonuclease Dicer [EC:3.1.26.-],RAB6A-GEF complex partner protein 2,actin-related protein 7, plant
BNTSVFungi (kingdom)endoribonuclease Dicer [EC:3.1.26.-],RAB6A-GEF complex partner protein 2
9UUU7Ascomycota (phylum)endoribonuclease Dicer [EC:3.1.26.-],RAB6A-GEF complex partner protein 2
C4FJRPezizomycotina (subphylum)endoribonuclease Dicer [EC:3.1.26.-],RAB6A-GEF complex partner protein 2
CHFP1Eurotiomycetes (class)endoribonuclease Dicer [EC:3.1.26.-]
7APM5Eurotiomycetidae (subclass)endoribonuclease Dicer [EC:3.1.26.-]
CJJ9WEurotiales (order)endoribonuclease Dicer [EC:3.1.26.-]
7KIM8Opisthokonta (clade)endoribonuclease Dicer [EC:3.1.26.-],RAB6A-GEF complex partner protein 2
CVT0CAspergillaceae (family)endoribonuclease Dicer [EC:3.1.26.-]
AQ9UBAspergillus (genus)endoribonuclease Dicer [EC:3.1.26.-]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: