Domains within Drosophila melanogaster protein PRIC1_DROME (A1Z6W3)

Protein prickle

Alternative representations: 1 /

Protein length1299 aa
Source databaseUniProt
Identifiers PRIC1_DROME, A1Z6W3, FBPP0088115, A1Z6V4, A1Z6V8, Q9N9H6, Q9U5X0, Q9U5X1, F3YDF9_DROME, F3YDF9
Source gene FBgn0003090
Alternative splicing A1Z6W3-2, PRIC1_DROME, A1Z6W3-3

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

PRIC1_DROME is shown as pk in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for pk

Protein PRIC1_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04310Wnt signaling pathway

KEGG orthologous groups

KONameDescription
K04511PRICKLEprickle

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 4 PTMs annotated in this protein:

PTMCount
Phosphorylation3
Prenylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein pk.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0088115 in eggNOG.

OGTaxonomic classDescription
LKOG1704All organisms (root)prickle,four and a half LIM domains protein 1,four and a half LIM domains protein 2
FE3EPmelanogaster subgroup (species subgroup)prickle
EJCZIEndopterygota (cohort)prickle
FUWHKmelanogaster group (species group)prickle
KOG1704Eukaryota (superkingdom)prickle,four and a half LIM domains protein 1,four and a half LIM domains protein 2
HURCVMetazoa (kingdom)prickle,mitochondrial import receptor subunit TOM6
HINRRArthropoda (phylum)prickle
86G0KHexapoda (subphylum)prickle
AHSR9Neoptera (infraclass)prickle
ANW3VDiptera (order)prickle
H6MGDBilateria (clade)prickle,mitochondrial import receptor subunit TOM6
7KB7UOpisthokonta (clade)prickle,mitochondrial import receptor subunit TOM6
EGVHVDrosophila (genus)prickle
50JTDSophophora (subgenus)prickle

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: