Domains within Drosophila melanogaster protein A1ZAW3_DROME (A1ZAW3)

FI17823p1

Alternative representations: 1 /

Protein length1004 aa
Source databaseUniProt
Identifiers A1ZAW3_DROME, A1ZAW3, FBPP0302900, FBPP0086058
Source gene FBgn0034249

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

A1ZAW3_DROME is shown as RhoGAP54D in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for RhoGAP54D

Protein A1ZAW3_DROME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04011MAPK signaling pathway - yeast

KEGG orthologous groups

KONameDescription
K20630CHN1_2, ARHGAP2_3chimaerin

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 8 PTMs annotated in this protein:

PTMCount
Phosphorylation5
Ubiquitination3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein RhoGAP54D.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 7227.FBpp0086058 in eggNOG.

OGTaxonomic classDescription
FUYHBmelanogaster group (species group)Rho GTPase-activating protein 19
FDWBXmelanogaster subgroup (species subgroup)Rho GTPase-activating protein 19
LKOG1453All organisms (root)chimaerin,Rho GTPase-activating protein 29/45,Rho GTPase-activating protein 19
EJ7BKEndopterygota (cohort)Rho GTPase-activating protein 19
KOG1453Eukaryota (superkingdom)chimaerin,Rho GTPase-activating protein 29/45,Rho GTPase-activating protein 19
HW9PWMetazoa (kingdom)Rho GTPase-activating protein 19
HI0B0Arthropoda (phylum)Rho GTPase-activating protein 19
86FETHexapoda (subphylum)Rho GTPase-activating protein 19
AGXABNeoptera (infraclass)Rho GTPase-activating protein 19
ANDFFDiptera (order)Rho GTPase-activating protein 19
H62YPBilateria (clade)Rho GTPase-activating protein 19
7KBQIOpisthokonta (clade)Rho GTPase-activating protein 19
EGX5XDrosophila (genus)Rho GTPase-activating protein 19
50M0ZSophophora (subgenus)Rho GTPase-activating protein 19

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: