Domains within Homo sapiens protein ARGFX_HUMAN (A6NJG6)

Arginine-fifty homeobox

Alternative representations: 1 /

Protein length315 aa
Source databaseUniProt
Identifiers ARGFX_HUMAN, A6NJG6, ENSP00000335578.3, ENSP00000335578
Source gene ENSG00000186103

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ARGFX_HUMAN is shown as ARGFX in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ARGFX

Protein ARGFX_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells

KEGG orthologous groups

KONameDescription
K18490OTX2homeobox protein OTX2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000335578 in eggNOG.

OGTaxonomic classDescription
LKOG2251All organisms (root)homeobox protein OTX2,homeobox protein OTX1,cone-rod homeobox protein
KOG2251Eukaryota (superkingdom)homeobox protein OTX2,homeobox protein OTX1,cone-rod homeobox protein
HV258Metazoa (kingdom)homeobox protein OTX2,cone-rod homeobox protein,homeobox protein OTX1
9407JChordata (phylum)cone-rod homeobox protein,leucine-twenty homeobox,arginine-fifty homeobox
5QJ8ESarcopterygii (superclass)cone-rod homeobox protein,arginine-fifty homeobox,leucine-twenty homeobox
8ZJ08Mammalia (class)cone-rod homeobox protein,arginine-fifty homeobox,leucine-twenty homeobox
4RCXZEuarchontoglires (superorder)arginine-fifty homeobox,leucine-twenty homeobox,cone-rod homeobox protein
4ZISTPrimates (order)arginine-fifty homeobox
98M1XHaplorrhini (suborder)arginine-fifty homeobox
BUZTGSimiiformes (infraorder)arginine-fifty homeobox
9EKD3Catarrhini (parvorder)arginine-fifty homeobox
9FNZJVertebrata (clade)cone-rod homeobox protein,arginine-fifty homeobox,leucine-twenty homeobox
7P3MROpisthokonta (clade)homeobox protein OTX2,cone-rod homeobox protein,homeobox protein OTX1
H3KH3Bilateria (clade)homeobox protein OTX2,cone-rod homeobox protein,homeobox protein OTX1
FX881Hominoidea (superfamily)arginine-fifty homeobox
5MX2UHominidae (family)arginine-fifty homeobox
5Y6CDHomininae (subfamily)arginine-fifty homeobox

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: