Domains within Homo sapiens protein TR64C_HUMAN (A6NLI5)

Tripartite motif-containing protein 64C

Alternative representations: 1 /

Protein length450 aa
Source databaseUniProt
Identifiers TR64C_HUMAN, A6NLI5, ENSP00000481815.1, ENSP00000481815, A0A087WYH8
Source gene ENSG00000214891

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

TR64C_HUMAN is shown as TRIM64C in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for TRIM64C

Protein TR64C_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05322Systemic lupus erythematosus
map04361Axon regeneration
map04120Ubiquitin mediated proteolysis
map05164Influenza A
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K12012TRIM35tripartite motif-containing protein 35
K06712BTN, CD277butyrophilin
K12019TRIM43Stripartite motif-containing protein 43/48/49/64/77

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000481815 in eggNOG.

OGTaxonomic classDescription
LKOG2177All organisms (root)butyrophilin,tripartite motif-containing protein 2/3,deltex [EC:2.3.2.27]
KOG2177Eukaryota (superkingdom)butyrophilin,tripartite motif-containing protein 2/3,deltex [EC:2.3.2.27]
HVPGDMetazoa (kingdom)butyrophilin,tripartite motif-containing protein 35,tripartite motif-containing protein 2/3
93S94Chordata (phylum)butyrophilin,tripartite motif-containing protein 35,tripartite motif-containing protein 16
5R91JSarcopterygii (superclass)butyrophilin,inducible T-cell co-stimulator ligand,tripartite motif-containing protein 39 [EC:2.3.2.27]
8Z7VUMammalia (class)tripartite motif-containing protein 43/48/49/64/77,tripartite motif-containing protein 11 [EC:2.3.2.27],tripartite motif-containing protein 21 [EC:2.3.2.27]
4RF26Euarchontoglires (superorder)tripartite motif-containing protein 43/48/49/64/77
4ZKDCPrimates (order)tripartite motif-containing protein 43/48/49/64/77
987A5Haplorrhini (suborder)tripartite motif-containing protein 43/48/49/64/77
BUYFZSimiiformes (infraorder)tripartite motif-containing protein 43/48/49/64/77
9F1KJCatarrhini (parvorder)tripartite motif-containing protein 43/48/49/64/77
7KUB7Opisthokonta (clade)butyrophilin,tripartite motif-containing protein 35,tripartite motif-containing protein 2/3
9FXMTVertebrata (clade)tripartite motif-containing protein 35,butyrophilin,tripartite motif-containing protein 16
H6GQGBilateria (clade)butyrophilin,tripartite motif-containing protein 35,tripartite motif-containing protein 2/3
FWZ3XHominoidea (superfamily)tripartite motif-containing protein 43/48/49/64/77
5NB75Hominidae (family)tripartite motif-containing protein 43/48/49/64/77
5Y222Homininae (subfamily)tripartite motif-containing protein 43/48/49/64/77

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: