Domains within Bos taurus protein GRAP_BOVIN (A6QLK6)

GRB2-related adapter protein

Alternative representations: 1 /

Protein length217 aa
Source databaseUniProt
Identifiers GRAP_BOVIN, A6QLK6, ENSBTAP00000041340.3, ENSBTAP00000041340
Source gene ENSBTAG00000003707

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

GRAP_BOVIN is shown as GRAP in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for GRAP

Protein GRAP_BOVIN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04660T cell receptor signaling pathway
map05203Viral carcinogenesis

KEGG orthologous groups

KONameDescription
K23694GRAPGRB2-related adapter protein
K04364GRB2growth factor receptor-bound protein 2

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9913.ENSBTAP00000041340 in eggNOG.

OGTaxonomic classDescription
LKOG3601All organisms (root)growth factor receptor-bound protein 2,GRB2-related adapter protein,GRB2-related adaptor protein 2
KOG3601Eukaryota (superkingdom)growth factor receptor-bound protein 2,GRB2-related adapter protein,GRB2-related adaptor protein 2
HVGN1Metazoa (kingdom)GRB2-related adapter protein,growth factor receptor-bound protein 2
94DKSChordata (phylum)GRB2-related adapter protein
5R7V1Sarcopterygii (superclass)GRB2-related adapter protein
8ZFK6Mammalia (class)GRB2-related adapter protein
BQEPMLaurasiatheria (superorder)GRB2-related adapter protein
AX8Z6Artiodactyla (order)GRB2-related adapter protein
B6CBWPecora (infraorder)GRB2-related adapter protein
H5SM3Bilateria (clade)GRB2-related adapter protein,growth factor receptor-bound protein 2
7H2WDOpisthokonta (clade)GRB2-related adapter protein,growth factor receptor-bound protein 2
9G920Vertebrata (clade)GRB2-related adapter protein
7PGQRBovidae (family)GRB2-related adapter protein
DB5D5Bovinae (subfamily)GRB2-related adapter protein
AZGWRBos (genus)GRB2-related adapter protein

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: