Domains within Frankia sp. EAN1pec protein A8LF50_FRASN (A8LF50)

Adenylate/guanylate cyclase with TPR repeats

Alternative representations: 1 /

Protein length1285 aa
Source databaseUniProt
Identifiers A8LF50_FRASN, A8LF50

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

A8LF50_FRASN is shown as ABW09795.1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ABW09795.1

Protein A8LF50_FRASN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04931Insulin resistance
map02025Biofilm formation - Pseudomonas aeruginosa

KEGG orthologous groups

KONameDescription
K12132prkC, stkPeukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1]
K01768E4.6.1.1adenylate cyclase [EC:4.6.1.1]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 298653.Franean1_0329 in eggNOG.

OGTaxonomic classDescription
LCOG2976All organisms (root)SARP family transcriptional regulator, regulator of embCAB operon,serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase [EC:3.4.16.4 3.4.21.-],protein O-GlcNAc transferase [EC:2.4.1.255]
LCOG3899All organisms (root)eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1],adenylate cyclase [EC:4.6.1.1],two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
LCOG2114All organisms (root)adenylate cyclase [EC:4.6.1.1],guanylate cyclase soluble subunit beta [EC:4.6.1.2],PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
COG3899Bacteria (superkingdom)eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1],adenylate cyclase [EC:4.6.1.1],two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
COG2114Bacteria (superkingdom)adenylate cyclase [EC:4.6.1.1],eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1],two-component system, sensor histidine kinase ChiS
COG2976Bacteria (superkingdom)SARP family transcriptional regulator, regulator of embCAB operon,serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase [EC:3.4.16.4 3.4.21.-],protein O-GlcNAc transferase [EC:2.4.1.255]
6A1R3Actinobacteria (phylum)adenylate cyclase [EC:4.6.1.1]
F9B9CActinomycetia (class)adenylate cyclase [EC:4.6.1.1]
8Y3BZFrankiales (order)Guanylate_cyc,AAA_16,TPR_12
AMRN8Frankiaceae (family)Guanylate_cyc,AAA_16,TPR_12
8E1ZEFrankia (genus)Guanylate_cyc,AAA_16,TPR_12

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: