Domains within Homo sapiens protein CEA18_HUMAN (A8MTB9)

Carcinoembryonic antigen-related cell adhesion molecule 18

Alternative representations: 1 /

Protein length384 aa
Source databaseUniProt
Identifiers CEA18_HUMAN, A8MTB9, ENSP00000379738.4, ENSP00000379738, C9JN24
Source gene ENSG00000213822

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

CEA18_HUMAN is shown as CEACAM18 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CEACAM18

Protein CEA18_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05166Human T-cell leukemia virus 1 infection

KEGG orthologous groups

KONameDescription
K10999CESAcellulose synthase A [EC:2.4.1.12]
K06867K06867uncharacterized protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000379738 in eggNOG.

OGTaxonomic classDescription
LCOG0666All organisms (root)uncharacterized protein,Mce-associated membrane protein,cellulose synthase A [EC:2.4.1.12]
KOG0504Eukaryota (superkingdom)cellulose synthase A [EC:2.4.1.12],beta-mannan synthase [EC:2.4.1.32],uncharacterized protein
HUF8QMetazoa (kingdom)carcinoembryonic antigen-related cell adhesion molecule
948GPChordata (phylum)carcinoembryonic antigen-related cell adhesion molecule
5R9VGSarcopterygii (superclass)carcinoembryonic antigen-related cell adhesion molecule
8YU5RMammalia (class)carcinoembryonic antigen-related cell adhesion molecule
4R6EJEuarchontoglires (superorder)carcinoembryonic antigen-related cell adhesion molecule
4ZK16Primates (order)carcinoembryonic antigen-related cell adhesion molecule
989FWHaplorrhini (suborder)carcinoembryonic antigen-related cell adhesion molecule
BV3WWSimiiformes (infraorder)carcinoembryonic antigen-related cell adhesion molecule
9EPJACatarrhini (parvorder)carcinoembryonic antigen-related cell adhesion molecule
7NRKBOpisthokonta (clade)carcinoembryonic antigen-related cell adhesion molecule
9FW33Vertebrata (clade)carcinoembryonic antigen-related cell adhesion molecule
H3Y6IBilateria (clade)carcinoembryonic antigen-related cell adhesion molecule
FX2HGHominoidea (superfamily)carcinoembryonic antigen-related cell adhesion molecule
5N4H2Hominidae (family)carcinoembryonic antigen-related cell adhesion molecule
5XX9MHomininae (subfamily)carcinoembryonic antigen-related cell adhesion molecule

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: