Domains within Rattus norvegicus protein B1WC31_RAT (B1WC31)

Meis homeobox 1

Alternative representations: 1 /

Protein length390 aa
Source databaseUniProt
Identifiers B1WC31_RAT, B1WC31, ENSRNOP00000006157.4, ENSRNOP00000006157
Source gene ENSRNOG00000004606

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

B1WC31_RAT is shown as Meis1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Meis1

Protein B1WC31_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04550Signaling pathways regulating pluripotency of stem cells
map04350TGF-beta signaling pathway

KEGG orthologous groups

KONameDescription
K24889IRXiroquois-class homeodomain protein IRX
K15613MEIS1homeobox protein Meis1
K24891PKNOXhomeobox protein PKNOX

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000006157 in eggNOG.

OGTaxonomic classDescription
LKOG0773All organisms (root)iroquois-class homeodomain protein IRX,homeobox protein PKNOX,homeobox protein Mohawk
KOG0773Eukaryota (superkingdom)iroquois-class homeodomain protein IRX,homeobox protein PKNOX,homeobox protein Mohawk
HVCW8Metazoa (kingdom)homeobox protein Meis1,homeobox protein Meis2
94BVRChordata (phylum)homeobox protein Meis1,homeobox protein Meis2
5QF7HSarcopterygii (superclass)homeobox protein Meis1
8Z3GGMammalia (class)homeobox protein Meis1
4RPJZEuarchontoglires (superorder)homeobox protein Meis1
AHY60Rodentia (order)homeobox protein Meis1
8DEZBMyomorpha (suborder)homeobox protein Meis1
H4Z7KBilateria (clade)homeobox protein Meis1,homeobox protein Meis2
9GN6IVertebrata (clade)homeobox protein Meis1,homeobox protein Meis2
7KV3FOpisthokonta (clade)homeobox protein PKNOX,homeobox protein TGIF1,homeobox protein TGIF2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: