Domains within Rattus norvegicus protein PTPRE_RAT (B2GV87)

Receptor-type tyrosine-protein phosphatase epsilon

Alternative representations: 1 /

Protein length699 aa
Source databaseUniProt
Identifiers PTPRE_RAT, B2GV87, ENSRNOP00000021359.6, ENSRNOP00000021359, Q63476, Q63477, B2GV87-3, Q9WV21_RAT, Q9WV21
Source gene ENSRNOG00000015717

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi/Metazoa group

Predicted functional partners

PTPRE_RAT is shown as Ptpre in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ptpre

Protein PTPRE_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04520Adherens junction
map05224Breast cancer
map04514Cell adhesion molecules

KEGG orthologous groups

KONameDescription
K07817PTPRNreceptor-type tyrosine-protein phosphatase N [EC:3.1.3.48]
K05695PTPRF, LARreceptor-type tyrosine-protein phosphatase F [EC:3.1.3.48]
K18033PTPREreceptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000021359 in eggNOG.

OGTaxonomic classDescription
LCOG5599All organisms (root)receptor-type tyrosine-protein phosphatase N [EC:3.1.3.48],tyrosine-protein phosphatase non-receptor type 12/18/22 [EC:3.1.3.48],tyrosine-protein phosphatase non-receptor type 14/21 [EC:3.1.3.48]
KOG4228Eukaryota (superkingdom)receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase A [EC:3.1.3.48]
HW1UQMetazoa (kingdom)receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase delta [EC:3.1.3.48]
93MKQChordata (phylum)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase A [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48]
5QUNKSarcopterygii (superclass)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]
8Z12FMammalia (class)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]
4RNDPEuarchontoglires (superorder)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]
AI0Z0Rodentia (order)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]
8D6E7Myomorpha (suborder)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]
H4SPWBilateria (clade)receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase delta [EC:3.1.3.48]
9GNV2Vertebrata (clade)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]
7GMZJOpisthokonta (clade)receptor-type tyrosine-protein phosphatase F [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48],receptor-type tyrosine-protein phosphatase delta [EC:3.1.3.48]
CQ2JSMuridae (family)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]
AE3D2Murinae (subfamily)receptor-type tyrosine-protein phosphatase epsilon [EC:3.1.3.48]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: