Domains within Mycobacterium marinum M protein B2HPP7_MYCMM (B2HPP7)

Regulator of sigma subunit, anti-anti-sigma factor RsbU

Alternative representations: 1 /

Protein length653 aa
Source databaseUniProt
Identifiers B2HPP7_MYCMM, B2HPP7

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Streptomyces avermitilis

Predicted functional partners

B2HPP7_MYCMM is shown as rsbU in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for rsbU

Protein B2HPP7_MYCMM is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map02020Two-component system
map02025Biofilm formation - Pseudomonas aeruginosa

KEGG orthologous groups

KONameDescription
K07315rsbU_Pphosphoserine phosphatase RsbU/P [EC:3.1.3.3]
K04749rsbVanti-sigma B factor antagonist
K04757rsbWserine/threonine-protein kinase RsbW [EC:2.7.11.1]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 216594.MMAR_3991 in eggNOG.

OGTaxonomic classDescription
LCOG2208All organisms (root)phosphoserine phosphatase RsbU/P [EC:3.1.3.3],two-component system, HptB-dependent secretion and biofilm response regulator,phosphoserine phosphatase RsbX [EC:3.1.3.3]
LCOG2172All organisms (root)serine/threonine-protein kinase RsbW [EC:2.7.11.1],serine/threonine-protein kinase RsbT [EC:2.7.11.1],stage II sporulation protein AB (anti-sigma F factor) [EC:2.7.11.1]
LCOG1366All organisms (root)anti-sigma B factor antagonist,rsbT co-antagonist protein RsbR,rsbT antagonist protein RsbS
COG2208Bacteria (superkingdom)phosphoserine phosphatase RsbU/P [EC:3.1.3.3],two-component system, HptB-dependent secretion and biofilm response regulator,phosphoserine phosphatase RsbX [EC:3.1.3.3]
COG1366Bacteria (superkingdom)anti-sigma B factor antagonist,rsbT co-antagonist protein RsbR,rsbT antagonist protein RsbS
COG2172Bacteria (superkingdom)serine/threonine-protein kinase RsbW [EC:2.7.11.1],serine/threonine-protein kinase RsbT [EC:2.7.11.1],stage II sporulation protein AB (anti-sigma F factor) [EC:2.7.11.1]
6A3ERActinobacteria (phylum)HATPase_c_2,SpoIIE,PAS_4
FBDIIActinomycetia (class)HATPase_c_2,SpoIIE,PAS_4
EN4W1Corynebacteriales (order)SpoIIE,HATPase_c_2,PAS_4
58FD2Mycobacteriaceae (family)SpoIIE,HATPase_c_2,PAS_4
HMT4AMycobacterium (genus)SpoIIE,HATPase_c_2,PAS_4

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: