Domains within Homo sapiens protein B7WPH3_HUMAN (B7WPH3)

Cat eye syndrome critical region protein 2

Alternative representations: 1 /

Protein length1300 aa
Source databaseUniProt
Identifiers B7WPH3_HUMAN, B7WPH3, ENSP00000383428.2, ENSP00000383428
Source gene ENSG00000099954
Alternative splicing B7WPH3_HUMAN, A0A087WT21_HUMAN, H0Y2Z1_HUMAN, CECR2_HUMAN, ENSP00000262608.10

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

B7WPH3_HUMAN is shown as CECR2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for CECR2

Protein B7WPH3_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05203Viral carcinogenesis

KEGG orthologous groups

KONameDescription
K06062PCAF, KAT2, GCN5histone acetyltransferase [EC:2.3.1.48]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000383428 in eggNOG.

OGTaxonomic classDescription
LKOG1472All organisms (root)histone acetyltransferase [EC:2.3.1.48],cat eye syndrome critical region protein 2,transcriptional activator SPT7
KOG1472Eukaryota (superkingdom)histone acetyltransferase [EC:2.3.1.48],cat eye syndrome critical region protein 2,transcriptional activator SPT7
HVESJMetazoa (kingdom)cat eye syndrome critical region protein 2,solute carrier family 25 (mitochondrial glutamate transporter), member 18/22
94AWCChordata (phylum)cat eye syndrome critical region protein 2,solute carrier family 25 (mitochondrial glutamate transporter), member 18/22
5RCFMSarcopterygii (superclass)cat eye syndrome critical region protein 2,solute carrier family 25 (mitochondrial glutamate transporter), member 18/22
8ZNTFMammalia (class)cat eye syndrome critical region protein 2,solute carrier family 25 (mitochondrial glutamate transporter), member 18/22
4RI5TEuarchontoglires (superorder)cat eye syndrome critical region protein 2,solute carrier family 25 (mitochondrial glutamate transporter), member 18/22
502NQPrimates (order)cat eye syndrome critical region protein 2
988HAHaplorrhini (suborder)cat eye syndrome critical region protein 2
BVHPPSimiiformes (infraorder)cat eye syndrome critical region protein 2
9F1VRCatarrhini (parvorder)cat eye syndrome critical region protein 2
9FUPCVertebrata (clade)cat eye syndrome critical region protein 2,solute carrier family 25 (mitochondrial glutamate transporter), member 18/22
7NH6BOpisthokonta (clade)cat eye syndrome critical region protein 2,protein SFI1,solute carrier family 25 (mitochondrial glutamate transporter), member 18/22
H4T9TBilateria (clade)cat eye syndrome critical region protein 2,solute carrier family 25 (mitochondrial glutamate transporter), member 18/22
FX45FHominoidea (superfamily)cat eye syndrome critical region protein 2
5N4RRHominidae (family)cat eye syndrome critical region protein 2
5Y1K7Homininae (subfamily)cat eye syndrome critical region protein 2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: