Domains within Sinorhizobium fredii NGR234 protein C3MI21_SINFN (C3MI21)

ATP-dependent zinc metalloprotease FtsH

Alternative representations: 1 /

Protein length645 aa
Source databaseUniProt
Identifiers A0A249NWM0_9RHIZ, A0A249NWM0, A0A2A6MAT8_9RHIZ, A0A2A6MAT8, A0A1L3L6M0_9RHIZ, A0A1L3L6M0, C3MI21_SINFN, C3MI21

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

C3MI21_SINFN is shown as ftsH in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ftsH

Protein C3MI21_SINFN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05017Spinocerebellar ataxia
map04139Mitophagy - yeast

KEGG orthologous groups

KONameDescription
K03798ftsH, hflBcell division protease FtsH [EC:3.4.24.-]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 394.NGR_c27760 in eggNOG.

OGTaxonomic classDescription
LCOG0465All organisms (root)cell division protease FtsH [EC:3.4.24.-],mitochondrial chaperone BCS1,AFG3 family protein [EC:3.4.24.-]
COG0465Bacteria (superkingdom)cell division protease FtsH [EC:3.4.24.-],AFG3 family protein [EC:3.4.24.-],transitional endoplasmic reticulum ATPase
61EYVProteobacteria (phylum)cell division protease FtsH [EC:3.4.24.-],ATP-dependent metalloprotease [EC:3.4.24.-]
80635Alphaproteobacteria (class)cell division protease FtsH [EC:3.4.24.-],ATP-dependent metalloprotease [EC:3.4.24.-]
D0IV6Hyphomicrobiales (order)cell division protease FtsH [EC:3.4.24.-],ATP-dependent metalloprotease [EC:3.4.24.-]
DQBQ0Rhizobiaceae (family)cell division protease FtsH [EC:3.4.24.-]
HNMQSSinorhizobium (genus)cell division protease FtsH [EC:3.4.24.-]
648JFSinorhizobium fredii (species)cell division protease FtsH [EC:3.4.24.-]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: