Domains within Homo sapiens protein ANR63_HUMAN (C9JTQ0)

Ankyrin repeat domain-containing protein 63

Alternative representations: 1 /

Protein length380 aa
Source databaseUniProt
Identifiers ANR63_HUMAN, C9JTQ0, ENSP00000399547.1, ENSP00000399547
Source gene ENSG00000230778

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

ANR63_HUMAN is shown as ANKRD63 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for ANKRD63

Protein ANR63_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03018RNA degradation
map04722Neurotrophin signaling pathway
map05166Human T-cell leukemia virus 1 infection

KEGG orthologous groups

KONameDescription
K10999CESAcellulose synthase A [EC:2.4.1.12]
K21440ANKRD50ankyrin repeat domain-containing protein 50
K06867K06867uncharacterized protein
K06499CEACAM, CD66carcinoembryonic antigen-related cell adhesion molecule

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000399547 in eggNOG.

OGTaxonomic classDescription
LCOG0666All organisms (root)uncharacterized protein,Mce-associated membrane protein,cellulose synthase A [EC:2.4.1.12]
KOG0504Eukaryota (superkingdom)cellulose synthase A [EC:2.4.1.12],beta-mannan synthase [EC:2.4.1.32],uncharacterized protein
HVG4IMetazoa (kingdom)ankyrin repeat domain-containing protein 50,serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A,serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
948EFChordata (phylum)ankyrin repeat domain-containing protein 50
5R9IRSarcopterygii (superclass)ankyrin repeat domain-containing protein 50
8ZHJQMammalia (class)ankyrin repeat domain-containing protein 50
4RFRIEuarchontoglires (superorder)Ank_2,Ank_4
4ZJ5HPrimates (order)Ank_2,Ank_4
988UYHaplorrhini (suborder)Ank_2,Ank_4
BV685Simiiformes (infraorder)Ank_2,Ank_4
9ESZ0Catarrhini (parvorder)Ank_2,Ank_4
7MMYUOpisthokonta (clade)carcinoembryonic antigen-related cell adhesion molecule,ankyrin repeat domain-containing protein 50,NF-kappa-B inhibitor alpha
H6IG9Bilateria (clade)ankyrin repeat domain-containing protein 50,serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A,serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
9GNMEVertebrata (clade)ankyrin repeat domain-containing protein 50
FX0WMHominoidea (superfamily)Ank_4,Ank_2
5N4MEHominidae (family)Ank_2
5XY1FHomininae (subfamily)Ank_2

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: