Domains within Ailuropoda melanoleuca protein D2HKA5_AILME (D2HKA5)

Uncharacterized protein (Fragment)

Alternative representations: 1 /

Protein length414 aa
Source databaseUniProt
Identifiers D2HKA5_AILME, D2HKA5, ENSAMEP00000009952.1, ENSAMEP00000009952
Source gene ENSAMEG00000009476

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

D2HKA5_AILME is shown as TARDBP in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for TARDBP

Protein D2HKA5_AILME is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03040Spliceosome
map05014Amyotrophic lateral sclerosis

KEGG orthologous groups

KONameDescription
K12741HNRNPA1_3heterogeneous nuclear ribonucleoprotein A1/A3
K23600TARDBP, TDP43TAR DNA-binding protein 43

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9646.ENSAMEP00000009952 in eggNOG.

OGTaxonomic classDescription
LKOG0118All organisms (root)heterogeneous nuclear ribonucleoprotein A1/A3,transformer-2 protein,serine/arginine-rich splicing factor 10
KOG0118Eukaryota (superkingdom)heterogeneous nuclear ribonucleoprotein A1/A3,transformer-2 protein,serine/arginine-rich splicing factor 10
HUDCDMetazoa (kingdom)TAR DNA-binding protein 43
93DQHChordata (phylum)TAR DNA-binding protein 43
5R9H0Sarcopterygii (superclass)TAR DNA-binding protein 43
8ZMHRMammalia (class)TAR DNA-binding protein 43
BQXT1Laurasiatheria (superorder)TAR DNA-binding protein 43
AQZN0Carnivora (order)TAR DNA-binding protein 43
HBQ5BCaniformia (suborder)TAR DNA-binding protein 43
H6KCNBilateria (clade)TAR DNA-binding protein 43
7NHF9Opisthokonta (clade)TAR DNA-binding protein 43
9G76JVertebrata (clade)TAR DNA-binding protein 43
E7HU1Ursidae (family)TAR DNA-binding protein 43

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: