Domains within Rattus norvegicus protein D3ZBQ1_RAT (D3ZBQ1)

Forkhead box O3

Alternative representations: 1 /

Protein length672 aa
Source databaseUniProt
Identifiers D3ZBQ1_RAT, D3ZBQ1, ENSRNOP00000000327.3, ENSRNOP00000000327, A0A096MJN1_RAT, A0A096MJN1
Source gene ENSRNOG00000000299
Alternative splicing D3ZBQ1_RAT, ENSRNOP00000068195.1

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi/Metazoa group

Predicted functional partners

D3ZBQ1_RAT is shown as Foxo3 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Foxo3

Protein D3ZBQ1_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04211Longevity regulating pathway
map04068FoxO signaling pathway
map05131Shigellosis

KEGG orthologous groups

KONameDescription
K09408FOXO3forkhead box protein O3
K07201FOXO1forkhead box protein O1
K09407FOXNforkhead box protein N

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 26 PTMs annotated in this protein:

PTMCount
Phosphorylation21
Acetylation5

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSRNOG00000000299.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000000327 in eggNOG.

OGTaxonomic classDescription
LKOG2294All organisms (root)forkhead box protein N,forkhead box protein D,forkhead box protein I
KOG2294Eukaryota (superkingdom)forkhead box protein N,forkhead box protein D,forkhead box protein I
HVYIBMetazoa (kingdom)forkhead box protein O3,forkhead box protein O1,forkhead box protein O4
94IH3Chordata (phylum)forkhead box protein O3,forkhead box protein O1,forkhead box protein O4
5R4PASarcopterygii (superclass)forkhead box protein O3,forkhead box protein O1
8Z2GMMammalia (class)forkhead box protein O3,forkhead box protein O1
4R9J2Euarchontoglires (superorder)forkhead box protein O3
AIBZ6Rodentia (order)forkhead box protein O3
8D3N6Myomorpha (suborder)forkhead box protein O3
7H334Opisthokonta (clade)forkhead box protein O3,forkhead box protein O1,forkhead box protein O4
H720WBilateria (clade)forkhead box protein O3,forkhead box protein O1,forkhead box protein O4
9G9AXVertebrata (clade)forkhead box protein O3,forkhead box protein O1,forkhead box protein O4
CQAHAMuridae (family)forkhead box protein O3
AE3MRMurinae (subfamily)forkhead box protein O3

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: