Domains within Rattus norvegicus protein D3ZCF7_RAT (D3ZCF7)

LDL receptor-related protein 12

Alternative representations: 1 /

Protein length858 aa
Source databaseUniProt
Identifiers D3ZCF7_RAT, D3ZCF7, ENSRNOP00000005668.4, ENSRNOP00000005668
Source gene ENSRNOG00000004152

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

D3ZCF7_RAT is shown as Lrp12 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Lrp12

Protein D3ZCF7_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05010Alzheimer disease

KEGG orthologous groups

KONameDescription
K20050LRP3_10_12low-density lipoprotein receptor-related protein 3/10/12

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 6 PTMs annotated in this protein:

PTMCount
Phosphorylation5
Ubiquitination1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSRNOG00000004152.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000005668 in eggNOG.

OGTaxonomic classDescription
LKOG1215All organisms (root)low-density lipoprotein receptor-related protein 3/10/12,low density lipoprotein receptor-related protein 5/6,low-density lipoprotein receptor-related protein 4
KOG1215Eukaryota (superkingdom)low-density lipoprotein receptor-related protein 3/10/12,low density lipoprotein receptor-related protein 5/6,low-density lipoprotein receptor-related protein 4
HTXW0Metazoa (kingdom)low-density lipoprotein receptor-related protein 3/10/12,WD repeat-containing protein 88
94F19Chordata (phylum)low-density lipoprotein receptor-related protein 3/10/12,WD repeat-containing protein 88
5QAXCSarcopterygii (superclass)low-density lipoprotein receptor-related protein 3/10/12,WD repeat-containing protein 88
8ZMT4Mammalia (class)low-density lipoprotein receptor-related protein 3/10/12,WD repeat-containing protein 88
4REV1Euarchontoglires (superorder)low-density lipoprotein receptor-related protein 3/10/12
AI9IJRodentia (order)low-density lipoprotein receptor-related protein 3/10/12
8D6E5Myomorpha (suborder)low-density lipoprotein receptor-related protein 3/10/12
7J0V0Opisthokonta (clade)low-density lipoprotein receptor-related protein 3/10/12,WD repeat-containing protein 88
H395GBilateria (clade)low-density lipoprotein receptor-related protein 3/10/12,WD repeat-containing protein 88
9FXABVertebrata (clade)low-density lipoprotein receptor-related protein 3/10/12,WD repeat-containing protein 88
CQ06AMuridae (family)low-density lipoprotein receptor-related protein 3/10/12
AEBR8Murinae (subfamily)low-density lipoprotein receptor-related protein 3/10/12

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: