Domains within Rattus norvegicus protein D3ZDU5_RAT (D3ZDU5)

Profilin

Alternative representations: 1 /

Protein length148 aa
Source databaseUniProt
Identifiers D3ZDU5_RAT, D3ZDU5, ENSRNOP00000061388.2, ENSRNOP00000061388, ENSRNOP00000062782.1, ENSRNOP00000062782, D4A9A4
Source gene ENSRNOG00000017427
Alternative splicing PROF2_RAT, D3ZDU5_RAT

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Eukaryota

Predicted functional partners

D3ZDU5_RAT is shown as Pfn2 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Pfn2

Protein D3ZDU5_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05132Salmonella infection

KEGG orthologous groups

KONameDescription
K05759PFNprofilin

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 19 PTMs annotated in this protein:

PTMCount
Phosphorylation9
Ubiquitination5
Acetylation4
Proteolytic cleavage1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Pfn2.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000061388 in eggNOG.

OGTaxonomic classDescription
LKOG1755All organisms (root)profilin
KOG1755Eukaryota (superkingdom)profilin
HUUZIMetazoa (kingdom)profilin
94IAWChordata (phylum)profilin
5R6ZTSarcopterygii (superclass)profilin
8ZEKHMammalia (class)profilin
4RKG3Euarchontoglires (superorder)profilin
AI9DWRodentia (order)profilin
8DHVAMyomorpha (suborder)profilin
7KP34Opisthokonta (clade)profilin
9FQ3TVertebrata (clade)profilin
H4WY4Bilateria (clade)profilin
CQB8FMuridae (family)profilin
AE31BMurinae (subfamily)profilin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: