Domains within Rattus norvegicus protein D4A1F4_RAT (D4A1F4)

Intracisternal A particle-promoted polypeptide

Alternative representations: 1 /

Protein length584 aa
Source databaseUniProt
Identifiers D4A1F4_RAT, D4A1F4, ENSRNOP00000070763.1, ENSRNOP00000070763, ENSRNOP00000021850.4, ENSRNOP00000021850
Source gene ENSRNOG00000016183

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

D4A1F4_RAT is shown as Ipp in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ipp

Protein D4A1F4_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04120Ubiquitin mediated proteolysis
map04340Hedgehog signaling pathway

KEGG orthologous groups

KONameDescription
K10443KLHL2_3kelch-like protein 2/3

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 9 PTMs annotated in this protein:

PTMCount
Phosphorylation4
Ubiquitination3
Acetylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSRNOG00000016183.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000021850 in eggNOG.

OGTaxonomic classDescription
LKOG4441All organisms (root)kelch-like protein 2/3,kelch-like protein 1/4/5,kelch-like protein 24/35
KOG4441Eukaryota (superkingdom)kelch-like protein 2/3,kelch-like protein 1/4/5,kelch-like protein 24/35
HSTN1Metazoa (kingdom)kelch-like protein 2/3,actin-binding protein IPP,kelch-like protein 12
94PD3Chordata (phylum)actin-binding protein IPP
5QE52Sarcopterygii (superclass)actin-binding protein IPP
8ZJEQMammalia (class)actin-binding protein IPP
4R5DXEuarchontoglires (superorder)actin-binding protein IPP
AI23VRodentia (order)actin-binding protein IPP
8D7SSMyomorpha (suborder)actin-binding protein IPP
9FKYKVertebrata (clade)actin-binding protein IPP
7NRIIOpisthokonta (clade)kelch-like protein 2/3,kelch-like protein 25/37 (ectoderm-neural cortex protein),actin-binding protein IPP
H6896Bilateria (clade)kelch-like protein 2/3,actin-binding protein IPP,kelch-like protein 12
CQ2QCMuridae (family)actin-binding protein IPP
AEC44Murinae (subfamily)actin-binding protein IPP

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: