Domains within Bos taurus protein E1BKN0_BOVIN (E1BKN0)

Lysine methyltransferase 2B

Alternative representations: 1 /

Protein length2711 aa
Source databaseUniProt
Identifiers E1BKN0_BOVIN, E1BKN0, ENSBTAP00000003584.5, ENSBTAP00000003584
Source gene ENSBTAG00000002763

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Homo sapiens

Predicted functional partners

E1BKN0_BOVIN is shown as KMT2B in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for KMT2B

Protein E1BKN0_BOVIN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map00310Lysine degradation iPath3
Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

KONameDescription
K22371G2H3G2/M phase-specific E3 ubiquitin-protein ligase [EC:2.3.2.26]
K07117K07117uncharacterized protein
K14959MLL4[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
K09186MLL1[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9913.ENSBTAP00000003584 in eggNOG.

OGTaxonomic classDescription
LCOG2940All organisms (root)uncharacterized protein,[histone H3]-lysine4/36 N-trimethyltransferase SMYD [EC:2.1.1.354 2.1.1.357],[histone H3]-lysine9 N-trimethyltransferase EHMT [EC:2.1.1.355]
KOG1084Eukaryota (superkingdom)G2/M phase-specific E3 ubiquitin-protein ligase [EC:2.3.2.26],PHD finger protein 6,transcription factor 20
HW4Y9Metazoa (kingdom)[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]
93XJ5Chordata (phylum)[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]
5R4TCSarcopterygii (superclass)[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
8Z6R3Mammalia (class)[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
BQI53Laurasiatheria (superorder)[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
AX6A0Artiodactyla (order)[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
B622VPecora (infraorder)[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
H48MMBilateria (clade)[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]
9FJY6Vertebrata (clade)[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
7I5VZOpisthokonta (clade)[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354],[histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]
7PQV0Bovidae (family)[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
DB4W2Bovinae (subfamily)[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
AZNHMBos (genus)[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: