Domains within Caldicellulosiruptor hydrothermalis 108 protein E4QAT8_CALH1 (E4QAT8)
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Alternative representations: 1 /
| Protein length | 663 aa |
|---|---|
| Source database | UniProt |
| Identifiers | E4QAT8_CALH1, E4QAT8 |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
This domain architecture was probably invented with the emergence of cellular organisms
Predicted functional partners
E4QAT8_CALH1 is shown as 
ispH in the network
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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein E4QAT8_CALH1 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map03010 | Ribosome |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K02945 | RP-S1, rpsA | small subunit ribosomal protein S1 | |
| K03527 | ispH, lytB | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] | iPath3 |
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 632292.Calhy_1399 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG0539 | All organisms (root) | small subunit ribosomal protein S1,rRNA biogenesis protein RRP5,4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] |
| LCOG0761 | All organisms (root) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4],small subunit ribosomal protein S1,CMP/dCMP kinase [EC:2.7.4.25] |
| COG0761 | Bacteria (superkingdom) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4],small subunit ribosomal protein S1,CMP/dCMP kinase [EC:2.7.4.25] |
| COG0539 | Bacteria (superkingdom) | small subunit ribosomal protein S1,4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4],S1 RNA binding domain protein |
| 9X0UI | Firmicutes (phylum) | small subunit ribosomal protein S1,4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] |
| 9A6CV | Clostridia (class) | small subunit ribosomal protein S1,4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] |
| B76JF | Thermoanaerobacterales (order) | small subunit ribosomal protein S1,4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] |
| 97TFJ | Thermoanaerobacterales Family III. Incertae Sedis (family) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4],small subunit ribosomal protein S1 |
| FYM35 | Caldicellulosiruptor (genus) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4],small subunit ribosomal protein S1 |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.