Domains within Homo sapiens protein A9YTQ3-2

Isoform 2 of Aryl hydrocarbon receptor repressor

Alternative representations: 1 /

Protein length719 aa
Source databaseUniProt
Identifiers A9YTQ3-2, ENSP00000323816.5, ENSP00000323816, E5RFG4_HUMAN, E5RFG4, A9YTQ3-3
Source gene ENSG00000063438
Alternative splicing AHRR_HUMAN, A9YTQ3-2, ENSP00000424880.1, E5RHE0_HUMAN, ENSP00000428893.1, G3V143_HUMAN, E5RGQ2_HUMAN, D6RE68_HUMAN, H0YA43_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

A9YTQ3-2 is shown as AHRR in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for AHRR

Protein A9YTQ3-2 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05207Chemical carcinogenesis - receptor activation

KEGG orthologous groups

KONameDescription
K09093AHRaryl hydrocarbon receptor

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 12 PTMs annotated in this protein:

PTMCount
Phosphorylation6
SUMOylation3
Ubiquitination3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein AHRR.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000323816 in eggNOG.

OGTaxonomic classDescription
LKOG3560All organisms (root)aryl hydrocarbon receptor,aryl hydrocarbon receptor repressor
KOG3560Eukaryota (superkingdom)aryl hydrocarbon receptor,aryl hydrocarbon receptor repressor
HSSF6Metazoa (kingdom)aryl hydrocarbon receptor repressor
949M4Chordata (phylum)aryl hydrocarbon receptor repressor
5QYJASarcopterygii (superclass)aryl hydrocarbon receptor repressor
8ZCV8Mammalia (class)aryl hydrocarbon receptor repressor
4RM8CEuarchontoglires (superorder)aryl hydrocarbon receptor repressor
4ZU1SPrimates (order)aryl hydrocarbon receptor repressor
98DN8Haplorrhini (suborder)aryl hydrocarbon receptor repressor
BVAJ3Simiiformes (infraorder)aryl hydrocarbon receptor repressor
9EZRICatarrhini (parvorder)aryl hydrocarbon receptor repressor
9FCZXVertebrata (clade)aryl hydrocarbon receptor repressor
7K0NZOpisthokonta (clade)aryl hydrocarbon receptor repressor
H5MYQBilateria (clade)aryl hydrocarbon receptor repressor
FWYH3Hominoidea (superfamily)aryl hydrocarbon receptor repressor
5N0KNHominidae (family)aryl hydrocarbon receptor repressor
5XZ8IHomininae (subfamily)aryl hydrocarbon receptor repressor

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: