Domains within Mus musculus protein CLUS_MOUSE (Q06890)

Clusterin

Alternative representations: 1 /

Protein length448 aa
Source databaseUniProt
Identifiers CLUS_MOUSE, Q06890, ENSMUSP00000022616.6, ENSMUSP00000022616, E9PXG5_MOUSE, E9PXG5, E9PUU2_MOUSE, E9PUU2, Q3V245_MOUSE, Q3V245, Q549A5_MOUSE, Q549A5, E9Q8Y5_MOUSE, E9Q8Y5, E9Q9B8_MOUSE, E9Q9B8
Source gene ENSMUSG00000022037
Alternative splicing CLUS_MOUSE, D6RFP9_MOUSE, ENSMUSP00000121633.1, ENSMUSP00000114720.1, ENSMUSP00000117555.1, ENSMUSP00000121485.1, E9Q2G2_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Euteleostomi

Predicted functional partners

CLUS_MOUSE is shown as Clu in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Clu

Protein CLUS_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04610Complement and coagulation cascades

KEGG orthologous groups

KONameDescription
K17252CLUclusterin

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 8 PTMs annotated in this protein:

PTMCount
Phosphorylation6
N-linked glycosylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Clu.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000022616 in eggNOG.

OGTaxonomic classDescription
730B1All organisms (root)clusterin
5HNFYEukaryota (superkingdom)clusterin
HU9K4Metazoa (kingdom)clusterin
94JWBChordata (phylum)clusterin
5R2VHSarcopterygii (superclass)clusterin
8YU4VMammalia (class)clusterin
4R43QEuarchontoglires (superorder)clusterin
AI1C0Rodentia (order)clusterin
8DMYEMyomorpha (suborder)clusterin
9FVUEVertebrata (clade)clusterin
H5YYQBilateria (clade)clusterin
7MCE7Opisthokonta (clade)clusterin
CQAABMuridae (family)clusterin
AE3Y7Murinae (subfamily)clusterin
5PHUUMus (genus)clusterin
HEDFXMus (subgenus)clusterin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: