Domains within Homo sapiens protein KCJ10_HUMAN (P78508)

ATP-sensitive inward rectifier potassium channel 10

Alternative representations: 1 /

Protein length379 aa
Source databaseUniProt
Identifiers KCJ10_HUMAN, P78508, ENSP00000495557.1, ENSP00000495557, ENSP00000357068.3, ENSP00000357068, ENSP00000492619.1, ENSP00000492619, ENSP00000491250.1, ENSP00000491250, A3KME7, Q5VUT9, Q8N4I7, Q92808, A0A2J8JAB0_PANTR, A0A2J8JAB0, A0A2J8VHG8_PONAB, A0A2J8VHG8, F6V197_MACMU, F6V197, A0A2J8JAB4_PANTR, A0A2J8JAB4, H2N557_PONAB, H2N557, G3S8U4_GORGO, G3S8U4, G7NWC2_MACFA, G7NWC2, A0A0D9SAL7_CHLSB, A0A0D9SAL7, Q9BXC5_HUMAN, Q9BXC5
Source gene ENSG00000177807
Alternative splicing A0A1W2PQC0_HUMAN, A0A1B0GUX2_HUMAN, A0A1W2PP61_HUMAN, A0A1W2PPI0_HUMAN, KCJ10_HUMAN, A0A1W2PQP0_HUMAN, A0A1W2PP51_HUMAN

Predicted functional partners

KCJ10_HUMAN is shown as KCNJ10 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for KCNJ10

Protein KCJ10_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease
map04971Gastric acid secretion
map04921Oxytocin signaling pathway

KEGG orthologous groups

KONameDescription
K05008KCNJ15, KIR4.2potassium inwardly-rectifying channel subfamily J member 15
K04997KCNJ3, KIR3.1potassium inwardly-rectifying channel subfamily J member 3
K05003KCNJ10, KIR4.1potassium inwardly-rectifying channel subfamily J member 10

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 39 PTMs annotated in this protein:

PTMCount
Phosphorylation36
Acetylation3

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein ENSPTRG00000030365.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000495557 in eggNOG.

OGTaxonomic classDescription
LKOG3827All organisms (root)potassium inwardly-rectifying channel subfamily J member 3,potassium inwardly-rectifying channel subfamily J member 1,potassium inwardly-rectifying channel subfamily J member 2
KOG3827Eukaryota (superkingdom)potassium inwardly-rectifying channel subfamily J member 3,potassium inwardly-rectifying channel subfamily J member 1,potassium inwardly-rectifying channel subfamily J member 2
HT4ZGMetazoa (kingdom)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
93X7BChordata (phylum)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
5QEMBSarcopterygii (superclass)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
8Z2BHMammalia (class)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
4R82HEuarchontoglires (superorder)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
4ZQSTPrimates (order)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
98E9JHaplorrhini (suborder)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
BV2IVSimiiformes (infraorder)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
9EH5QCatarrhini (parvorder)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
H4R4HBilateria (clade)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
9GDK4Vertebrata (clade)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
7I0V7Opisthokonta (clade)potassium inwardly-rectifying channel subfamily J member 15,potassium inwardly-rectifying channel subfamily J member 10
FWZIEHominoidea (superfamily)potassium inwardly-rectifying channel subfamily J member 10
5N020Hominidae (family)potassium inwardly-rectifying channel subfamily J member 10
5XSVWHomininae (subfamily)potassium inwardly-rectifying channel subfamily J member 10

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: