Domains within Rattus norvegicus protein F1LR25_RAT (F1LR25)

Hepatocyte nuclear factor 3-alpha

Alternative representations: 1 /

Protein length466 aa
Source databaseUniProt
Identifiers F1LR25_RAT, F1LR25, ENSRNOP00000009940.6, ENSRNOP00000009940
Source gene ENSRNOG00000009284

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi/Metazoa group

Predicted functional partners

F1LR25_RAT is shown as Foxa1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Foxa1

Protein F1LR25_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04950Maturity onset diabetes of the young
map04212Longevity regulating pathway - worm

KEGG orthologous groups

KONameDescription
K08035FOXA2, HNF3Bforkhead box protein A2, hepatocyte nuclear factor 3-beta

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000009940 in eggNOG.

OGTaxonomic classDescription
LKOG3563All organisms (root)forkhead box protein A1, hepatocyte nuclear factor 3-alpha,forkhead box protein A2, hepatocyte nuclear factor 3-beta,forkhead box protein A3, hepatocyte nuclear factor 3-gamma
KOG3563Eukaryota (superkingdom)forkhead box protein A1, hepatocyte nuclear factor 3-alpha,forkhead box protein A2, hepatocyte nuclear factor 3-beta,forkhead box protein A3, hepatocyte nuclear factor 3-gamma
HTXNQMetazoa (kingdom)forkhead box protein A1, hepatocyte nuclear factor 3-alpha,forkhead box protein A2, hepatocyte nuclear factor 3-beta
93RXNChordata (phylum)forkhead box protein A1, hepatocyte nuclear factor 3-alpha,forkhead box protein A2, hepatocyte nuclear factor 3-beta
5QKG8Sarcopterygii (superclass)forkhead box protein A1, hepatocyte nuclear factor 3-alpha,forkhead box protein A2, hepatocyte nuclear factor 3-beta
8Z0SZMammalia (class)forkhead box protein A1, hepatocyte nuclear factor 3-alpha
4R4GDEuarchontoglires (superorder)forkhead box protein A1, hepatocyte nuclear factor 3-alpha
AHZCWRodentia (order)forkhead box protein A1, hepatocyte nuclear factor 3-alpha
8DCZPMyomorpha (suborder)forkhead box protein A1, hepatocyte nuclear factor 3-alpha
H5N14Bilateria (clade)forkhead box protein A1, hepatocyte nuclear factor 3-alpha,forkhead box protein A2, hepatocyte nuclear factor 3-beta
9GUSRVertebrata (clade)forkhead box protein A1, hepatocyte nuclear factor 3-alpha,forkhead box protein A2, hepatocyte nuclear factor 3-beta
7H8CSOpisthokonta (clade)forkhead box protein A1, hepatocyte nuclear factor 3-alpha,forkhead box protein A2, hepatocyte nuclear factor 3-beta
CQDJMMuridae (family)forkhead box protein A1, hepatocyte nuclear factor 3-alpha
AE5GZMurinae (subfamily)forkhead box protein A1, hepatocyte nuclear factor 3-alpha

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: