Domains within Rattus norvegicus protein F1M9C0_RAT (F1M9C0)

Mitogen-activated protein kinase-activated protein kinase 2

Alternative representations: 1 /

Protein length370 aa
Source databaseUniProt
Identifiers F1M9C0_RAT, F1M9C0, ENSRNOP00000057786.4, ENSRNOP00000057786
Source gene ENSRNOG00000004726

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

F1M9C0_RAT is shown as Mapkapk2 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Mapkapk2

Protein F1M9C0_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04010MAPK signaling pathway
map04370VEGF signaling pathway
map05203Viral carcinogenesis

KEGG orthologous groups

KONameDescription
K04443MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K04444MAPKAPK3mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000057786 in eggNOG.

OGTaxonomic classDescription
LKOG0604All organisms (root)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1],mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1],mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]
KOG0604Eukaryota (superkingdom)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1],mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1],mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]
HSMGNMetazoa (kingdom)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1],mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1],nuclear receptor subfamily 2 group C
93N95Chordata (phylum)mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1],mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
5QI6USarcopterygii (superclass)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
8Z0XQMammalia (class)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
4RFYJEuarchontoglires (superorder)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
AHZUNRodentia (order)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
8DIF3Myomorpha (suborder)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
7IRD8Opisthokonta (clade)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1],mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1],nuclear receptor subfamily 2 group C
9GN1QVertebrata (clade)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
H64DYBilateria (clade)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1],mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1],nuclear receptor subfamily 2 group C
CQ9KEMuridae (family)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
ADXCRMurinae (subfamily)mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: