Domains within Bos taurus protein F1MWF0_BOVIN (F1MWF0)

Huntingtin interacting protein 1

Alternative representations: 1 /

Protein length1037 aa
Source databaseUniProt
Identifiers F1MWF0, F1MWF0_BOVIN, ENSBTAP00000001039.5, ENSBTAP00000001039
Source gene ENSBTAG00000000781

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi/Metazoa group

Predicted functional partners

F1MWF0_BOVIN is shown as HIP1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for HIP1

Protein F1MWF0_BOVIN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K04559HIP1huntingtin interacting protein 1
K20040HIP1R, SLA2huntingtin-interacting protein 1-related protein

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9913.ENSBTAP00000001039 in eggNOG.

OGTaxonomic classDescription
LKOG0980All organisms (root)huntingtin-interacting protein 1-related protein,huntingtin interacting protein 1,nuclear pore complex protein Nup121
KOG0980Eukaryota (superkingdom)huntingtin-interacting protein 1-related protein,huntingtin interacting protein 1,nuclear pore complex protein Nup121
HTXQQMetazoa (kingdom)huntingtin-interacting protein 1-related protein,huntingtin interacting protein 1,nuclear pore complex protein Nup121
93U7QChordata (phylum)huntingtin-interacting protein 1-related protein,huntingtin interacting protein 1,nuclear pore complex protein Nup121
5QSNESarcopterygii (superclass)huntingtin interacting protein 1,nuclear pore complex protein Nup121
8Z5AXMammalia (class)huntingtin interacting protein 1,nuclear pore complex protein Nup121
BQU9XLaurasiatheria (superorder)huntingtin interacting protein 1
AX26CArtiodactyla (order)huntingtin interacting protein 1
B688YPecora (infraorder)huntingtin interacting protein 1
7MTMYOpisthokonta (clade)huntingtin-interacting protein 1-related protein,huntingtin interacting protein 1,nuclear pore complex protein Nup121
H4FBSBilateria (clade)huntingtin-interacting protein 1-related protein,huntingtin interacting protein 1,nuclear pore complex protein Nup121
9FZ3ZVertebrata (clade)huntingtin-interacting protein 1-related protein,huntingtin interacting protein 1,nuclear pore complex protein Nup121
7PSNDBovidae (family)huntingtin interacting protein 1
DB1DEBovinae (subfamily)huntingtin interacting protein 1
AZJ94Bos (genus)huntingtin interacting protein 1

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: