Domains within Polymorphum gilvum SL003B-26A1 protein F2J5A0_POLGS (F2J5A0)
Putative isopropylmalate synthase (LeuA-like)
Alternative representations: 1 /
| Protein length | 531 aa |
|---|---|
| Source database | UniProt |
| Identifiers | F2J5A0_POLGS, F2J5A0 |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
Predicted functional partners
F2J5A0_POLGS is shown as 
leuA1 in the network
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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein F2J5A0_POLGS is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map00620 | Pyruvate metabolism | iPath3 |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K01649 | leuA, IMS | 2-isopropylmalate synthase [EC:2.3.3.13] | iPath3 |
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 991905.SL003B_2736 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| 6HJRY | Alphaproteobacteria incertae sedis (no rank) | 2-isopropylmalate synthase [EC:2.3.3.13] |
| LCOG0119 | All organisms (root) | 2-isopropylmalate synthase [EC:2.3.3.13],hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4],4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39] |
| COG0119 | Bacteria (superkingdom) | 2-isopropylmalate synthase [EC:2.3.3.13],hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4],4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39] |
| 5ZHE8 | Proteobacteria (phylum) | 2-isopropylmalate synthase [EC:2.3.3.13],4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39],homocitrate synthase NifV [EC:2.3.3.14] |
| 80W24 | Alphaproteobacteria (class) | 2-isopropylmalate synthase [EC:2.3.3.13],homocitrate synthase NifV [EC:2.3.3.14],4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.