Domains within Isoptericola variabilis 225 protein F6FWH1_ISOV2 (F6FWH1)
Methionine synthase
Alternative representations: 1 /
| Protein length | 1191 aa |
|---|---|
| Source database | UniProt |
| Identifiers | F6FWH1_ISOV2, F6FWH1 |
Domain architecture analysis
Display all proteins with similar:
| Domain organisation | Proteins having all the domains as the query in the same order. Additional domains are allowed. |
|---|---|
| Domain composition | Proteins with the same domain composition have at least one copy of each of the domains of the query. |
Predicted functional partners
F6FWH1_ISOV2 is shown as 
AEG44545.1 in the network
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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.
Protein F6FWH1_ISOV2 is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:
KEGG pathways
| Pathway | Description | |
|---|---|---|
| map00450 | Selenocompound metabolism | iPath3 |
KEGG orthologous groups
| KO | Name | Description | |
|---|---|---|---|
| K00548 | metH, MTR | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] | iPath3 |
Orthologous groups
Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 743718.Isova_1799 in eggNOG.
| OG | Taxonomic class | Description |
|---|---|---|
| LCOG0646 | All organisms (root) | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13],homocysteine S-methyltransferase [EC:2.1.1.10],methionine synthase / methylenetetrahydrofolate reductase (NADH) [EC:2.1.1.13 1.5.1.54] |
| LCOG1410 | All organisms (root) | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13],5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase [EC:2.1.1.258],MerR family transcriptional regulator, light-induced transcriptional regulator |
| COG0646 | Bacteria (superkingdom) | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13],methionine synthase / methylenetetrahydrofolate reductase (NADH) [EC:2.1.1.13 1.5.1.54],betaine-homocysteine S-methyltransferase [EC:2.1.1.5] |
| COG1410 | Bacteria (superkingdom) | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13],5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase [EC:2.1.1.258],MerR family transcriptional regulator, light-induced transcriptional regulator |
| 6AHPD | Actinobacteria (phylum) | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13],beta-glucuronidase [EC:3.2.1.31],beta-galactosidase [EC:3.2.1.23] |
| FAQYU | Actinomycetia (class) | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13],methionine synthase / methylenetetrahydrofolate reductase (NADH) [EC:2.1.1.13 1.5.1.54] |
| EWDMH | Micrococcales (order) | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] |
| DQXVG | Promicromonosporaceae (family) | 5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13] |
The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.