Domains within Rattus norvegicus protein G3V746_RAT (G3V746)

Glutamate receptor ionotropic, NMDA 2B

Alternative representations: 1 /

Protein length1482 aa
Source databaseUniProt
Identifiers G3V746_RAT, G3V746, ENSRNOP00000011697.3, ENSRNOP00000011697
Source gene ENSRNOG00000008766

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

Predicted functional partners

G3V746_RAT is shown as Grin2b in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Grin2b

Protein G3V746_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease
map04024cAMP signaling pathway
map04724Glutamatergic synapse

KEGG orthologous groups

KONameDescription
K05210GRIN2Bglutamate receptor ionotropic, NMDA 2B

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 35 PTMs annotated in this protein:

PTMCount
Phosphorylation31
Ubiquitination2
N-linked glycosylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Grin2b.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000011697 in eggNOG.

OGTaxonomic classDescription
LKOG1053All organisms (root)glutamate receptor ionotropic, NMDA 2B,glutamate receptor ionotropic, NMDA 3A,glutamate receptor ionotropic, NMDA 2C
KOG1053Eukaryota (superkingdom)glutamate receptor ionotropic, NMDA 2B,glutamate receptor ionotropic, NMDA 3A,glutamate receptor ionotropic, NMDA 2C
HSV0WMetazoa (kingdom)glutamate receptor ionotropic, NMDA 2B,glutamate receptor ionotropic, NMDA 2C,glutamate receptor ionotropic, NMDA 2A
93ENKChordata (phylum)glutamate receptor ionotropic, NMDA 2B,glutamate receptor ionotropic, NMDA 2C,glutamate receptor ionotropic, NMDA 2A
5RCGMSarcopterygii (superclass)glutamate receptor ionotropic, NMDA 2B
8Z5Q5Mammalia (class)glutamate receptor ionotropic, NMDA 2B
4RQDTEuarchontoglires (superorder)glutamate receptor ionotropic, NMDA 2B
AIEWURodentia (order)glutamate receptor ionotropic, NMDA 2B
8DI4TMyomorpha (suborder)glutamate receptor ionotropic, NMDA 2B
7IZWWOpisthokonta (clade)glutamate receptor ionotropic, NMDA 2B,glutamate receptor ionotropic, NMDA 2C,glutamate receptor ionotropic, NMDA 2A
9FE5SVertebrata (clade)glutamate receptor ionotropic, NMDA 2B,glutamate receptor ionotropic, NMDA 2C,glutamate receptor ionotropic, NMDA 2A
H607JBilateria (clade)glutamate receptor ionotropic, NMDA 2B,glutamate receptor ionotropic, NMDA 2C,glutamate receptor ionotropic, NMDA 2A
CQES0Muridae (family)glutamate receptor ionotropic, NMDA 2B
AEDG1Murinae (subfamily)glutamate receptor ionotropic, NMDA 2B

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: