Domains within Mus musculus protein GLP1R_MOUSE (O35659)

Glucagon-like peptide 1 receptor

Alternative representations: 1 /

Protein length463 aa
Source databaseUniProt
Identifiers GLP1R_MOUSE, O35659, ENSMUSP00000110221.1, ENSMUSP00000110221, Q1JQR8, Q3ZAW0_MOUSE, Q3ZAW0
Source gene ENSMUSG00000024027

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

GLP1R_MOUSE is shown as Glp1r in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Glp1r

Protein GLP1R_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04080Neuroactive ligand-receptor interaction

KEGG orthologous groups

KONameDescription
K04583GCGRglucagon receptor
K04589VIPR1vasoactive intestinal peptide receptor 1
K04581GLP1Rglucagon-like peptide 1 receptor

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 13 PTMs annotated in this protein:

PTMCount
Phosphorylation7
N-linked glycosylation3
ADP ribosylation2
Nitration1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Glp1r.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000110221 in eggNOG.

OGTaxonomic classDescription
LKOG4564All organisms (root)vasoactive intestinal peptide receptor 1,calcitonin receptor-like,parathyroid hormone receptor 1
KOG4564Eukaryota (superkingdom)vasoactive intestinal peptide receptor 1,calcitonin receptor-like,parathyroid hormone receptor 1
HVJ33Metazoa (kingdom)glucagon receptor,glucagon-like peptide 2 receptor,glucagon-like peptide 1 receptor
94VN2Chordata (phylum)glucagon receptor,glucagon-like peptide 2 receptor,glucagon-like peptide 1 receptor
5R4TQSarcopterygii (superclass)glucagon-like peptide 1 receptor
8ZF3BMammalia (class)glucagon-like peptide 1 receptor
4R7R6Euarchontoglires (superorder)glucagon-like peptide 1 receptor
AI4KYRodentia (order)glucagon-like peptide 1 receptor
8DCKGMyomorpha (suborder)glucagon-like peptide 1 receptor
7J9VUOpisthokonta (clade)glucagon receptor,glucagon-like peptide 2 receptor,glucagon-like peptide 1 receptor
9FNUFVertebrata (clade)glucagon receptor,glucagon-like peptide 2 receptor,glucagon-like peptide 1 receptor
H3RRTBilateria (clade)glucagon receptor,glucagon-like peptide 2 receptor,glucagon-like peptide 1 receptor
CPZ7DMuridae (family)glucagon-like peptide 1 receptor
AE5PPMurinae (subfamily)glucagon-like peptide 1 receptor
5PWCNMus (genus)glucagon-like peptide 1 receptor
HE1V0Mus (subgenus)glucagon-like peptide 1 receptor

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: