Domains within Mus musculus protein NEUS_MOUSE (O35684)

Neuroserpin

Alternative representations: 1 /

Protein length410 aa
Source databaseUniProt
Identifiers NEUS_MOUSE, O35684, ENSMUSP00000029423.8, ENSMUSP00000029423, Q543F7, Q922U6, E0CYW0_MOUSE, E0CYW0
Source gene ENSMUSG00000027834
Alternative splicing ENSMUSP00000123845.1, NEUS_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

NEUS_MOUSE is shown as Serpini1 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Serpini1

Protein NEUS_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04610Complement and coagulation cascades

KEGG orthologous groups

KONameDescription
K04525SERPINAserpin A

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000029423 in eggNOG.

OGTaxonomic classDescription
LCOG4826All organisms (root)serpin A,serpin B,serpin peptidase inhibitor, clade H, member 1
KOG2392Eukaryota (superkingdom)serpin A,serpin B,serpin peptidase inhibitor, clade H, member 1
HTCWEMetazoa (kingdom)serpin A,serpin B,leukocyte elastase inhibitor
93X6JChordata (phylum)neuroserpin
5QBX1Sarcopterygii (superclass)neuroserpin
8Z11YMammalia (class)neuroserpin
4RF60Euarchontoglires (superorder)neuroserpin
AIASBRodentia (order)neuroserpin
8DJ6AMyomorpha (suborder)neuroserpin
7HDH9Opisthokonta (clade)serpin A,serpin B,leukocyte elastase inhibitor
H4UFABilateria (clade)serpin A,serpin B,leukocyte elastase inhibitor
9GMVVVertebrata (clade)neuroserpin
CQ5W2Muridae (family)neuroserpin
AE9V6Murinae (subfamily)neuroserpin
5PHF5Mus (genus)neuroserpin
HEF59Mus (subgenus)neuroserpin

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: