Domains within Mus musculus protein WISP1_MOUSE (O54775)

WNT1-inducible-signaling pathway protein 1

Alternative representations: 1 /

Protein length367 aa
Source databaseUniProt
Identifiers WISP1_MOUSE, O54775, ENSMUSP00000005255.2, ENSMUSP00000005255, Q80ZL1, Q3UFJ5_MOUSE, Q3UFJ5, A0A0R4J1T7_MOUSE, A0A0R4J1T7
Source gene ENSMUSG00000005124
Alternative splicing WISP1_MOUSE, ENSMUSP00000117402.1, D3Z6X6_MOUSE

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Chordata

Predicted functional partners

WISP1_MOUSE is shown as Ccn4 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Ccn4

Protein WISP1_MOUSE is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04310Wnt signaling pathway
map04371Apelin signaling pathway

KEGG orthologous groups

KONameDescription
K06829CYR61, CCN1, IGFBP10insulin-like growth factor-binding protein 10
K22471CCN4, WISP1CCN family member 4

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 4 PTMs annotated in this protein:

PTMCount
Phosphorylation4

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein Wisp1.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10090.ENSMUSP00000005255 in eggNOG.

OGTaxonomic classDescription
76T4NAll organisms (root)insulin-like growth factor-binding protein 10,connective tissue growth factor (insulin-like growth factor-binding protein 8),CCN family member 4
5EE0REukaryota (superkingdom)insulin-like growth factor-binding protein 10,connective tissue growth factor (insulin-like growth factor-binding protein 8),CCN family member 4
HSU3PMetazoa (kingdom)CCN family member 4
94NDWChordata (phylum)CCN family member 4
5RA0SSarcopterygii (superclass)CCN family member 4
8Z8VKMammalia (class)CCN family member 4
4R545Euarchontoglires (superorder)CCN family member 4
AIF2TRodentia (order)CCN family member 4
8DD2CMyomorpha (suborder)CCN family member 4
H3FZWBilateria (clade)CCN family member 4
7KP0AOpisthokonta (clade)CCN family member 4,insulin-like growth factor-binding protein 9,connective tissue growth factor (insulin-like growth factor-binding protein 8)
9G8MCVertebrata (clade)CCN family member 4
CQ487Muridae (family)CCN family member 4
AED4HMurinae (subfamily)CCN family member 4
5PRXRMus (genus)CCN family member 4
HEEFFMus (subgenus)CCN family member 4

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: