Domains within Schizosaccharomyces pombe 972h- protein AFG2_SCHPO (O60058)

ATPase family gene 2 protein

Alternative representations: 1 /

Protein length809 aa
Source databaseUniProt
Identifiers AFG2_SCHPO, O60058

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

AFG2_SCHPO is shown as SPBC56F2.07c in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for SPBC56F2.07c

Protein AFG2_SCHPO is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map03008Ribosome biogenesis in eukaryotes
map04141Protein processing in endoplasmic reticulum
map05022Pathways of neurodegeneration - multiple diseases
map05014Amyotrophic lateral sclerosis

KEGG orthologous groups

KONameDescription
K14575AFG2, DRG1, SPATA5AAA family ATPase
K13525VCP, CDC48transitional endoplasmic reticulum ATPase

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 7 PTMs annotated in this protein:

PTMCount
Ubiquitination4
Phosphorylation2
Methylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein afg2.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 284812.O60058 in eggNOG.

OGTaxonomic classDescription
FRPXTDikarya (subkingdom)AAA family ATPase
LCOG0464All organisms (root)transitional endoplasmic reticulum ATPase,vesicle-fusing ATPase [EC:3.6.4.6],ATPase family AAA domain-containing protein 1 [EC:3.6.1.-]
KOG0730Eukaryota (superkingdom)transitional endoplasmic reticulum ATPase,AAA family ATPase,transient receptor potential cation channel subfamily A member 1
BP52AFungi (kingdom)AAA family ATPase
9UG08Ascomycota (phylum)AAA family ATPase
DVEP0Taphrinomycotina (subphylum)AAA family ATPase
7ICZKOpisthokonta (clade)transitional endoplasmic reticulum ATPase,AAA family ATPase,GPI ethanolamine phosphate transferase 3 subunit O [EC:2.7.-.-]
CE4V4Schizosaccharomyces (genus)AAA family ATPase

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: