Domains within Caenorhabditis elegans protein O61792_CAEEL (O61792)

Proteasome Regulatory Particle, Non-ATPase-like

Alternative representations: 1 /

Protein length362 aa
Source databaseUniProt
Identifiers O61792_CAEEL, O61792, R12E2.3
Source gene WBGene00004464

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of cellular organisms

Predicted functional partners

O61792_CAEEL is shown as rpn-8 in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for rpn-8

Protein O61792_CAEEL is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map05016Huntington disease

KEGG orthologous groups

KONameDescription
K03038PSMD7, RPN826S proteasome regulatory subunit N8

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 12 PTMs annotated in this protein:

PTMCount
Ubiquitination7
Phosphorylation3
Acetylation2

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein rpn-8.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 6239.R12E2.3.1 in eggNOG.

OGTaxonomic classDescription
LCOG1310All organisms (root)26S proteasome regulatory subunit N11,26S proteasome regulatory subunit N8,STAM-binding protein [EC:3.4.19.12]
KOG1556Eukaryota (superkingdom)26S proteasome regulatory subunit N8
HUZ5MMetazoa (kingdom)26S proteasome regulatory subunit N8
8AI5SNematoda (phylum)26S proteasome regulatory subunit N8
HDGIDChromadorea (class)26S proteasome regulatory subunit N8
6EDSYRhabditida (order)26S proteasome regulatory subunit N8
8PMTCRhabditina (suborder)26S proteasome regulatory subunit N8
7J7BDOpisthokonta (clade)26S proteasome regulatory subunit N8
H3MKZBilateria (clade)26S proteasome regulatory subunit N8
AYE6RRhabditidae (family)26S proteasome regulatory subunit N8
BT1EYCaenorhabditis (genus)26S proteasome regulatory subunit N8

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: