Domains within Homo sapiens protein KI21B_HUMAN (O75037)

Kinesin-like protein KIF21B

Alternative representations: 1 /

Protein length1637 aa
Source databaseUniProt
Identifiers KI21B_HUMAN, O75037, ENSP00000411831.2, ENSP00000411831, B2RP62, B7ZMI0, Q5T4J3
Source gene ENSG00000116852
Alternative splicing O75037-2, O75037-4, O75037-3, KI21B_HUMAN

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Fungi/Metazoa group

Predicted functional partners

KI21B_HUMAN is shown as KIF21B in the network

Click and drag to pan the network, and zoom by using your mouse wheel. Click the protein nodes for additional options.

The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for KIF21B

Protein KI21B_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04914Progesterone-mediated oocyte maturation
map04340Hedgehog signaling pathway

KEGG orthologous groups

KONameDescription
K18806KIF7kinesin family member 7
K11498CENPE, KIF10centromeric protein E

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000411831 in eggNOG.

OGTaxonomic classDescription
LKOG0242All organisms (root)centromeric protein E,kinesin family member 18/19,kinesin family member 22
KOG0242Eukaryota (superkingdom)centromeric protein E,kinesin family member 18/19,kinesin family member 22
HSMUIMetazoa (kingdom)kinesin family member 7,kinesin family member 27,kinesin family member 21
93NEBChordata (phylum)kinesin family member 21
5R9XFSarcopterygii (superclass)kinesin family member 21
8ZCXKMammalia (class)kinesin family member 21
4R3Z7Euarchontoglires (superorder)kinesin family member 21
501YNPrimates (order)kinesin family member 21
98JTAHaplorrhini (suborder)kinesin family member 21
BV2CCSimiiformes (infraorder)kinesin family member 21
9EU88Catarrhini (parvorder)kinesin family member 21
7JC47Opisthokonta (clade)kinesin family member 7,kinesin family member 27,kinesin family member 21
H6KQFBilateria (clade)kinesin family member 7,kinesin family member 21,kinesin family member 27
9FD91Vertebrata (clade)kinesin family member 21
FWZSHHominoidea (superfamily)kinesin family member 21
5N5U3Hominidae (family)kinesin family member 21
5Y5ZQHomininae (subfamily)kinesin family member 21

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: