Domains within Rattus norvegicus protein CELR3_RAT (O88278)

Cadherin EGF LAG seven-pass G-type receptor 3

Alternative representations: 1 /

Protein length3313 aa
Source databaseUniProt
Identifiers CELR3_RAT, O88278, ENSRNOP00000068821.1, ENSRNOP00000068821
Source gene ENSRNOG00000053889

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Chordata

Predicted functional partners

CELR3_RAT is shown as Celsr3 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for Celsr3

Protein CELR3_RAT is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04978Mineral absorption
map05208Chemical carcinogenesis - reactive oxygen species
map04391Hippo signaling pathway - fly

KEGG orthologous groups

KONameDescription
K04602CELSR3cadherin EGF LAG seven-pass G-type receptor 3
K04601CELSR2cadherin EGF LAG seven-pass G-type receptor 2
K04600CELSR1cadherin EGF LAG seven-pass G-type receptor 1

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 10116.ENSRNOP00000068821 in eggNOG.

OGTaxonomic classDescription
LKOG4289All organisms (root)cadherin EGF LAG seven-pass G-type receptor 1,cadherin EGF LAG seven-pass G-type receptor 2,cadherin EGF LAG seven-pass G-type receptor 3
KOG4289Eukaryota (superkingdom)cadherin EGF LAG seven-pass G-type receptor 1,cadherin EGF LAG seven-pass G-type receptor 2,cadherin EGF LAG seven-pass G-type receptor 3
HVWSXMetazoa (kingdom)cadherin EGF LAG seven-pass G-type receptor 1,cadherin EGF LAG seven-pass G-type receptor 2,cadherin EGF LAG seven-pass G-type receptor 3
944WDChordata (phylum)cadherin EGF LAG seven-pass G-type receptor 1,cadherin EGF LAG seven-pass G-type receptor 2,cadherin EGF LAG seven-pass G-type receptor 3
5QDT0Sarcopterygii (superclass)cadherin EGF LAG seven-pass G-type receptor 2,cadherin EGF LAG seven-pass G-type receptor 3,cadherin EGF LAG seven-pass G-type receptor 1
8YX40Mammalia (class)cadherin EGF LAG seven-pass G-type receptor 3,solute carrier family 26 (sulfate anion transporter), member 6
4RC0WEuarchontoglires (superorder)cadherin EGF LAG seven-pass G-type receptor 3
AICMFRodentia (order)cadherin EGF LAG seven-pass G-type receptor 3
8D5DCMyomorpha (suborder)cadherin EGF LAG seven-pass G-type receptor 3
9GGDIVertebrata (clade)cadherin EGF LAG seven-pass G-type receptor 1,cadherin EGF LAG seven-pass G-type receptor 2,cadherin EGF LAG seven-pass G-type receptor 3
7M7BPOpisthokonta (clade)cadherin EGF LAG seven-pass G-type receptor 1,cadherin EGF LAG seven-pass G-type receptor 2,cadherin EGF LAG seven-pass G-type receptor 3
H3A9EBilateria (clade)cadherin EGF LAG seven-pass G-type receptor 1,cadherin EGF LAG seven-pass G-type receptor 2,cadherin EGF LAG seven-pass G-type receptor 3
CQE8FMuridae (family)cadherin EGF LAG seven-pass G-type receptor 3
AE50JMurinae (subfamily)cadherin EGF LAG seven-pass G-type receptor 3

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: