Domains within Homo sapiens protein KBTBB_HUMAN (O94819)

Kelch repeat and BTB domain-containing protein 11

Alternative representations: 1 /

Protein length623 aa
Source databaseUniProt
Identifiers KBTBB_HUMAN, O94819, ENSP00000321544.3, ENSP00000321544, ENSP00000481889.1, ENSP00000481889, Q3L1I0, B6IDD2_9ZZZZ, B6IDD2, B6IDD3_9ZZZZ, B6IDD3
Source gene ENSG00000273645

Domain architecture analysis

Display all proteins with similar:

Domain organisationProteins having all the domains as the query in the same order. Additional domains are allowed.
Domain compositionProteins with the same domain composition have at least one copy of each of the domains of the query.

This domain architecture was probably invented with the emergence of Bilateria

Predicted functional partners

KBTBB_HUMAN is shown as KBTBD11 in the network

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The network on the left comes from STRING, a database of known and predicted protein interactions. Displayed here is the evidence view, where different line colors represent the types of evidence for the association.

Open the STRING annotation page for KBTBD11

Protein KBTBB_HUMAN is possibly involved in these pathways, based on its similarity to the listed KEGG orthologous groups:

KEGG pathways

PathwayDescription
map04120Ubiquitin mediated proteolysis

KEGG orthologous groups

KONameDescription
K10449KLHL11kelch-like protein 11

Post-translational modifications

PTM annotation is taken from PTMcode, a resource of known and predicted functional associations between protein post-translational modifications (PTMs). There are 11 PTMs annotated in this protein:

PTMCount
Phosphorylation10
Acetylation1

To see the full details, including possible functional associations between the PTMs, please visit the PTMcode annotation page for protein KBTBD11.

Orthologous groups

Orthology information is taken from eggNOG, a database of orthologous groups of genes. Orthologous groups containing this protein are listed below. This protein is named 9606.ENSP00000321544 in eggNOG.

OGTaxonomic classDescription
LKOG1072All organisms (root)kelch-like protein 11,kelch repeat and BTB domain-containing protein 13,kelch-like protein 33
KOG1072Eukaryota (superkingdom)kelch-like protein 11,kelch repeat and BTB domain-containing protein 13,kelch-like protein 33
HW8SNMetazoa (kingdom)kelch repeat and BTB domain-containing protein 11
94FEVChordata (phylum)kelch repeat and BTB domain-containing protein 11
5R95BSarcopterygii (superclass)kelch repeat and BTB domain-containing protein 11
8ZDRAMammalia (class)kelch repeat and BTB domain-containing protein 11
4RR5ZEuarchontoglires (superorder)kelch repeat and BTB domain-containing protein 11
4ZX16Primates (order)kelch repeat and BTB domain-containing protein 11
98ND3Haplorrhini (suborder)kelch repeat and BTB domain-containing protein 11
BV8VXSimiiformes (infraorder)kelch repeat and BTB domain-containing protein 11
9EYG8Catarrhini (parvorder)kelch repeat and BTB domain-containing protein 11
H54G5Bilateria (clade)kelch repeat and BTB domain-containing protein 11
9FZAXVertebrata (clade)kelch repeat and BTB domain-containing protein 11
7H1UUOpisthokonta (clade)kelch repeat and BTB domain-containing protein 11
FX32MHominoidea (superfamily)kelch repeat and BTB domain-containing protein 11
5N5KHHominidae (family)kelch repeat and BTB domain-containing protein 11
5Y3IDHomininae (subfamily)kelch repeat and BTB domain-containing protein 11

The SMART diagram above represents a summary of the results shown below. Domains with scores less significant than established cutoffs are not shown in the diagram. Features are also not shown when two or more occupy the same piece of sequence; the priority for display is given by SMART > PFAM > PROSPERO repeats > Signal peptide > Transmembrane > Coiled coil > Low complexity. In either case, features not shown in the above diagram are listed in the right side table below, and the reason for their omission is shown in the 'Reason' column.

Confidently predicted domains, repeats, motifs and features:

Outlier homologues and homologues of known structure:

Features NOT shown in the diagram: